System and method for noninvasive analysis of subcutaneous tissue
Inventors
Klein, Ronnie • ZILBERMAN, Arkadi • Cohen, Yaniv • Dekel, Ben Zion
Assignees
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Publication Number
US-10772541-B2
Publication Date
2020-09-15
Expiration Date
Abstract
Systems, devices and methods for noninvasive analysis of tissue, by irradiating a surface of the tissue with infrared radiation such that an interaction of the radiation with a component of the tissue other than water in two spectral bands is substantially identical, measuring an intensity of the radiation that emerges from the tissue in each of the spectral bands, determining change in at least one of shape and intensity of signals received by the at least one radiation detector, calculating a relative absorption by the tissue of radiation in one of the first and second spectral bands relative to absorption by the tissue of radiation in the other of the first and second spectral bands, and determining concentration of a predetermined substance, in accordance with the calculated relative absorption and in accordance with determined change in the received signal.
Core Innovation
A noninvasive analysis of tissue is performed by irradiating a surface of the tissue with infrared radiation and measuring, using a plurality of radiation detectors at different lateral distances from the source, an intensity of the radiation that emerges from the tissue. The measured signals are used to determine a change in at least one of shape and intensity of the signals received by the radiation detectors. The wavelength of the infrared radiation is limited to at least one of the ranges: 500 nm to 900 nm, 1000 nm to 1350 nm, and 1500 nm to 2100 nm.
A processor determines concentration of a predetermined medication in accordance with the determined change in at least one of shape and intensity of signals and in accordance with the distance between the corresponding radiation detector and the at least one source of infrared radiation. The disclosure includes determining changes in signal shape and intensity to infer tissue state and to infer concentrations of an introduced substance in blood, with an emphasis on Propofol as the predetermined medication. The approach includes using radiation emerging from the irradiated surface and/or through tissue.
The disclosed concept is further broadened by using spectral selection and alternative spectroscopic modalities. Spectral components can be selected using optical spectral-selection hardware including dispersive elements and a micro-mirror array. Alternative measurement modalities are also discussed, including Raman spectroscopy and ATR spectroscopy / FTIR-ATR / EW-FTIR, and the disclosure references related classification/multivariate methods (PLS, PCR, LDA, kNN, NBC, SVM, ANN) for interpreting spectral data to infer tissue state or concentrations.
Claims Coverage
The partial content includes three independent claims covering a method, a system, and a device. Across these claims, the inventive coverage centers on noninvasive infrared tissue irradiation with spatially separated detectors, processor-based determination of changes in signal shape and/or intensity, and medication concentration determination that accounts for source-detector distance within specified infrared wavelength ranges.
Distance-resolved noninvasive infrared irradiation and multi-detector emerging radiation measurement
Irradiating a surface of the tissue with infrared radiation and measuring an intensity of the radiation that emerges from the tissue with a plurality of radiation detectors at different lateral distances from the source.
Processor determination of signal change in shape and/or intensity
Determining, by a processor, a change in at least one of shape and intensity of signals received by the radiation detectors.
Medication concentration determination based on signal change and detector-source distance
Determining, by the processor, concentration of a predetermined medication in accordance with the determined change in at least one of shape and intensity of signals and in accordance with the distance between the corresponding radiation detector and the at least one source of infrared radiation.
Specified infrared wavelength ranges for noninvasive tissue analysis
The infrared radiation is in the wavelength range of at least one of: 500 nm to 900 nm, 1000 nm to 1350 nm and 1500 nm to 2100 nm.
Device with removable base and movable transceiver portion for spacing-aware measurement
Providing a base configured to be removably attachable to skin tissue, a clipping element removably attachable to the base, and a transceiver portion coupled to the clipping element; the clipping element is configured to move the transceiver portion relative to the base in at least one direction, while the transceiver includes at least one infrared radiation source, plurality of detectors at different lateral distances, and a processor to calculate signal change and determine Propofol concentration in accordance with distance.
The independent claims collectively require noninvasive infrared irradiation and measurement of emerging radiation with multiple detectors at different lateral distances, followed by processor determination of signal changes in shape and/or intensity and concentration determination of a predetermined medication, with Propofol specified in the independent claims, using the detector-to-source distance and constrained infrared wavelength ranges.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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