Test apparatus and target measurement method using the same
Inventors
Lee, Sung Hwa • Taguchi, Takayuki • Park, Hye Kyung
Assignees
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Publication Number
US-10761101-B2
Publication Date
2020-09-01
Expiration Date
Abstract
A test apparatus and method for measuring a concentration of a target by correcting for an impact of hemoglobin are provided. The target measurement method includes measuring an absorbance of hemoglobin in a sample, measuring an absorbance of a target in the sample, determining variation of the absorbance of the target according to the measured absorbance of the hemoglobin, and correcting the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target.
Core Innovation
The invention relates to a target measurement method for biochemical samples in which hemoglobin-induced optical interference is removed. The method measures an absorbance of hemoglobin in the sample and an absorbance of a target in the sample, and uses a control relationship to model how the target absorbance varies with the measured absorbance of the hemoglobin.
The method determines a variation of the absorbance of the target according to the measured absorbance of the hemoglobin based on a pre-determined correlation showing the variation of the absorbance of the target according to the absorbance of the hemoglobin. The determining and the pre-determined correlation provide an explicit dependence of the target absorbance variation on hemoglobin absorbance.
The method corrects the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target. The corrected target concentration is thus obtained after correction by subtraction, and the described approach is implemented using a measurement apparatus including a light emitter and a light receiver, and a controller that stores the pre-determined correlation/equation and performs the correction, with documented examples directed to TBIL in serum or blood plasma.
Claims Coverage
The independent claim covers one inventive feature focused on correcting target absorbance based on hemoglobin variation using a pre-determined correlation.
Correcting target absorbance based on hemoglobin variation using pre-determined correlation
Measuring an absorbance of hemoglobin in a sample; measuring an absorbance of a target in the sample; determining a variation of the absorbance of the target according to the measured absorbance of the hemoglobin; and correcting the absorbance of the target by subtracting the determined variation of the absorbance of the target from the measured absorbance of the target, wherein the determining comprises determining the variation of the absorbance of the target according to the measured absorbance of the hemoglobin based on a pre-determined correlation showing the variation of the absorbance of the target according to the absorbance of the hemoglobin.
Claim coverage focuses on modeling hemoglobin’s influence on target absorbance via a pre-determined correlation and then correcting the measured target absorbance by subtracting the determined hemoglobin-dependent variation.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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