Vaporized medicants and methods of use
Inventors
Chong, Alexander ChinHak • Bartkowski, William P. • Thompson, Marshall A.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-10758582-B2
Publication Date
2020-09-01
Expiration Date
Abstract
A method and formulation for delivering an active analgesic compound, such as an opiate, in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the active compound. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer.
Core Innovation
The invention is directed to delivering medicants through inhalation by acquiring a medicant solution suitable for vaporization and vaporizing the medicant solution to provide an effective inhalation serving. The medicant solution comprises an inert non-reactive excipient and an active ingredient, including analgesics such as opioids, and the vaporizing is performed at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. using a vaporizer.
A central concept is the use of an inert non-reactive excipient having a lower heat of vaporization, where the excipient vaporizes to carry an active ingredient without destroying the active ingredient or excipient. Non-reactive excipients include propylene glycol, vegetable glycerin, and polysorbates, including polysorbate 20, 40, 60, and 80, and water and alcohol can be optionally present.
The disclosed framework includes low-temperature vaporized inhalation using a low temperature vaporizer with a mouthpiece. It further supports medicants such as tobacco constituents and monoamine oxidase inhibitors, stimulants such as caffeine, sleep aids such as melatonin and diphenhydramine, including doxylamine, and analgesics or opioids such as morphine, codeine, oxycodone, and fentanyl.
Claims Coverage
The provided claims coverage identifies three independent claim themes, each centered on delivering medicants through inhalation by vaporizing a medicant solution at approximately 90 degrees C. to approximately 385 degrees C. The inventive features focus on the vaporized inhalation delivery, an inert non-reactive excipient system carrying an analgesic, and a fentanyl-containing composition with specified excipient components.
Inhalation delivery using a vaporized medicant solution at 90°C to 385°C with a vaporizer
A method for delivering medicants through inhalation by acquiring a medicant solution suitable for vaporization and vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. such that an effective serving of the medicant solution is provided to a user for inhalation, wherein the step of vaporizing the medicant solution comprises using a vaporizer.
Excipient system comprising inert non-reactive components to carry an analgesic
A method for delivering medicants through inhalation by acquiring a medicant solution suitable for vaporization, the medicant solution comprising an excipient comprising an inert non-reactive compound and an analgesic, and vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. such that an effective serving of the analgesic is provided to the user for inhalation using a low temperature vaporizer with a mouthpiece.
Fentanyl in a medicant solution with specified propylene glycol, vegetable glycerin, water, and alcohol percentages
A method for delivering medicants through inhalation wherein the medicant solution comprises an excipient comprising propylene glycol present at approximately 1 percent to approximately 30 percent of the excipient, vegetable glycerin present at approximately 1 percent to approximately 30 percent of the excipient, water present at approximately 0.01 percent to approximately 30 percent of the excipient, and alcohol present at approximately 0.01 percent to approximately 30 percent of the excipient, and fentanyl, and the medicant solution is vaporized at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. using a vaporizer to provide an effective serving for inhalation.
The claims collectively focus on inhalation delivery by vaporizing a medicant solution at approximately 90 degrees C. to approximately 385 degrees C., using an inert non-reactive excipient to carry an analgesic, and a fentanyl embodiment with specified excipient components, including delivery using a low temperature vaporizer with a mouthpiece.
Stated Advantages
Provides effective servings of the medicant solution for inhalation.
Enables inhalation delivery using a low temperature vaporizer with a mouthpiece.
Carries an active ingredient using an inert non-reactive excipient that has a lower heat of vaporization.
Vaporization is described as providing delivery without destroying the active ingredient or excipient.
Documented Applications
Delivery of fentanyl through inhalation using a vaporized medicant solution.
Delivery of analgesics through inhalation using an inert non-reactive excipient and a low temperature vaporizer with a mouthpiece.
Delivery of tobacco constituents and monoamine oxidase inhibitors through inhalation.
Delivery of stimulants such as caffeine through inhalation.
Delivery of sleep aids such as melatonin and diphenhydramine, including doxylamine, through inhalation.
Delivery of opioids and analgesics such as morphine, codeine, and oxycodone through inhalation.
Interested in licensing this patent?