Methods of use and processes for preparing alcoholic solutions of polyvinylpyridine polymers
Inventors
BOULOUSSA, Houssam • Bouloussa, Othman
Assignees
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Publication Number
US-10743539-B2
Publication Date
2020-08-18
Expiration Date
Abstract
Provided is a process for preparing an alcoholic solution of a polyvinylpyridine polymer having biocidal and biocompatibility properties. The alcoholic solution is ready-to-graft in order to confer biocidal properties to various surfaces and to prevent biofilm formation on such surfaces. Also provided are methods of using the alcoholic solution, such as for controlling the growth of bacteria, fungi and/or viruses, and/or for preventing digestion of wood cellulose by wood-boring insects.
Core Innovation
The invention describes a one-step reaction process to prepare an alcoholic solution comprising a polymer of formula II by reacting polyvinylpyridine, iodopropyltrimethoxysilane, and bromobutane in an alcoholic solvent. The resulting alcoholic solution is characterized in terms of polymer quaternization via the N+N ratio for formula II, and the disclosed process is presented as ready-to-graft.
The invention also describes a one-step reaction process to prepare an alcoholic solution comprising a polymer of formula I by reacting polyvinylpyridine, chloromethylcatechol, and bromobutane in an alcoholic solvent. For both formula types, the preparation is configured to achieve a specified quaternization N+N ratio, and in the partially quaternized polyvinylpyridine context, a fixed 5% proportion of iodopropyltrimethoxysilane is stated to prevent reticulation in volume during storage.
The ready-to-graft alcoholic solutions are intended to be covalently grafted onto activated surfaces for controlling microbial growth and associated biofilm formation. The document additionally extends the grafting concept to wood cellulose to prevent cellulose digestion by wood-boring insects, where the described mechanisms include direct enzyme inhibition and indirect killing of enzyme-producing gut microbes/protozoa.
Claims Coverage
The document includes two independent claims. Each independent claim defines a one-step process for preparing a ready-to-graft alcoholic solution by reacting polyvinylpyridine with a defined quaternizing/silane or chloromethylcatechol plus bromobutane in an alcoholic solvent, with coverage further tied to polymer quaternization via the N+N ratio and, for the formula II embodiment, a fixed reagent proportion to prevent reticulation in volume.
One-step reaction process for formula II alcoholic solution
A one-step reaction process to prepare an alcoholic solution comprising a polymer of formula II by reacting polyvinylpyridine, iodopropyltrimethoxysilane, and bromobutane in an alcoholic solvent.
One-step reaction process for formula I alcoholic solution
A one-step reaction process to prepare an alcoholic solution comprising a polymer of formula I by reacting polyvinylpyridine, chloromethylcatechol, and bromobutane in an alcoholic solvent.
Ready-to-graft deposition and grafting onto activated surface for microbial control
A method for controlling the growth of at least one of bacteria, fungi, and viruses, comprising depositing and grafting on an activated surface an alcoholic solution prepared by the applicable one-step reaction process.
Cellulose digestion prevention by grafting onto wood cellulose
A use case in which the grafting of the prepared alcoholic solution onto wood cellulose prevents digestion by wood-boring insects, including direct enzyme inhibition and indirect killing of enzyme-producing gut microbes/protozoa.
Overall, the independent claim scope is focused on preparing partially quaternized polyvinylpyridine alcoholic solutions through one-step reactions in an alcoholic solvent. The claim refinements captured in the partial content relate to controlling polymer quaternization via an N+N ratio, specifying a fixed reagent proportion to prevent reticulation in volume, and limiting downstream use to deposition and grafting onto activated surfaces for controlling bacteria, fungi, and viruses and to wood cellulose for preventing insect-driven digestion.
Stated Advantages
Prevents reticulation in volume during storage via a fixed 5% proportion of iodopropyltrimethoxysilane.
Controls the growth of bacteria, fungi, and viruses by depositing and grafting the alcoholic solution on an activated surface.
Prevents wood cellulose digestion by wood-boring insects, including direct enzyme inhibition and indirect killing of enzyme-producing gut microbes/protozoa.
Provides biocidal and biocompatibility properties as supported by the described in vitro outcomes.
Documented Applications
Covalent grafting onto activated surfaces, including plasma/piranha-activated titanium, to control MRSA biofilms.
Controlling the growth of at least one of bacteria, fungi, and viruses by depositing and grafting the prepared alcoholic solution on an activated surface.
Preventing digestion of wood cellulose by wood-boring insects via grafting onto cellulose, with described direct enzyme inhibition and indirect killing of enzyme-producing gut microbes/protozoa.
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