Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Assignees
Member
FreMon ScientificFreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
FreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
Publication Number
US-10732083-B2
Publication Date
2020-08-04
Expiration Date
Abstract
Dry thawing systems and devices for thawing biological substances are provided herein. Methods for thawing biological substances are also provided.
Core Innovation
Dry thawing devices and systems thaw an enclosed biological substance received within a chamber frame by generating thermal energy without using a water-bath heating approach. Heat is applied through heating assemblies and heating cushions in thermal communication with the enclosed biological substance, with heating controlled by commands issued to a heating assembly that selectively generates thermal energy in response to receipt of a command signal.
A chamber includes heating assemblies configured to generate thermal energy for thawing, and an agitation mechanism arranged to pivot or oscillate at least one of the heating assemblies or an agitator plate. The chamber door pivots or slides to seal a cavity around a bag or overwrap containing the enclosed biological substance, and the system can include a removable chamber and a controller for operation.
Temperature and load are measured using temperature sensors and a weight sensor, and the controller generates command signals based upon the measured temperature(s) representing a temperature of a predetermined portion of the heating assembly and a temperature of the enclosed biological substance, as well as the measured weight. Heating control is performed across multiple operation stages, with command signal generation based on closed-loop feedback, stage-specific control settings, transition and final temperature set points, and safety timers/alarms that stop heating when thawing or standby exceeds limits.
Claims Coverage
The disclosed claims include one independent method claim that covers thawing an enclosed biological substance by chamber-frame loading, measuring temperatures at both the heating assembly and the biological substance, measuring weight, and using the measured values to generate controller command signals that control the heating assembly temperature.
Chamber-frame receipt of enclosed biological substance
Receiving, within a chamber frame, the enclosed biological substance.
Temperature measurement at heating assembly portion
Measuring, by a first temperature sensor, a first temperature representing a temperature of a predetermined portion of a heating assembly, the heating assembly being in thermal communication with the enclosed biological substance received within the chamber frame and configured to selectively generate thermal energy in response to receipt of a command signal.
Temperature measurement of enclosed biological substance
Measuring, by a second temperature sensor, a second temperature representing a temperature of the enclosed biological substance.
Weight measurement of enclosed biological substance
Measuring, by a weight sensor, a weight of the enclosed biological substance.
Controller command-signal generation based on first temperature, second temperature, and weight
Receiving, by a controller in communication with the heating assembly, the first temperature, the second temperature, and the weight, and generating, by the controller, at least one command signal based upon the first temperature, the second temperature, and the weight, wherein the command signal is operative to control a temperature generated by the heating assembly.
Across the independent claim, the main inventive core is the combination of chamber-frame loading of an enclosed biological substance, dual temperature sensing that separately represents heating-assembly temperature and substance temperature, weight sensing, and controller generation of command signals based on the sensed parameters to control the heating assembly temperature.
Stated Advantages
Documented Applications
No documented applications found
Interested in licensing this patent?