Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance
Inventors
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Assignees
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FreMon ScientificFreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
FreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
Publication Number
US-10722623-B2
Publication Date
2020-07-28
Expiration Date
Abstract
A cost-effective, single use bag or container is provided for storing biological substances that incorporates on its inner wall an electronic device that is configured to measure physiological and/or physical parameters of the enclosed biological substances, such as source history, identification, demographics, time stamping, temperature, pH, conductivity, glucose, O2, CO2 levels etc. The electronic device of the disclosed bag comprises a sensor configured to measure physiological and/or physical parameters of the biological substances enclosed within the bag, and a radio-frequency (RF) device communicably coupled to the sensor and configured to: (a) acquire from the sensor data associated with the measured parameters, (b) store the acquired sensor data in nonvolatile memory, and (c) communicate the stored data wirelessly to a RF reader.
Core Innovation
The invention provides a modular dry thawing apparatus for thawing biological substances. The apparatus includes a container comprising a chamber, an enclosure containing a biological substance positioned within the chamber, and cushion devices disposed in the chamber so that thermal energy is transferred from the cushion devices to the enclosure.
Each cushion device includes heating elements and heat transfer structures to enable controlled thawing. A temperature sensor is disposed within the chamber, and an agitator is disposed within the container and configured to agitate the biological substance contained within the enclosure.
The invention further supports modular configurations using opposing cushion devices and enclosure placement between them. In one configuration, a first pair of cushion devices positioned opposite each other defines a chamber therebetween, with the enclosure positioned within the chamber between the cushion devices; in another configuration, first and second cushion devices are positioned within the chamber on opposite sides so that thermal energy is transferred from both cushion devices to the enclosure.
The disclosure also describes variations that can include overwrap bag enclosures, internal controller regulation based on temperature sensor readings, adjustable cushion positioning to change chamber size, and additional opposing cushion-device pairs to define additional modular chambers.
Claims Coverage
The independent claims are directed to modular dry thawing apparatuses that combine a chambered container, cushion-heater structures with thermally conductive or heat-conducting layers, an enclosure for biological substance, a temperature sensor in the chamber, and an agitator for agitating the biological substance. Across the independent claims, the coverage focuses on opposed-cushion geometries, direct attachment of heat-conducting layers to heating elements, and temperature-sensing and agitation integration.
Modular dry thawing apparatus with chambered container and cushion heater contacting an enclosure
A container comprising a chamber; a cushion device disposed within and positioned on one side of the chamber with a heat conducting layer directly attached to a heating element configured to generate thermal energy; an enclosure containing a biological substance positioned within the chamber adjacent the cushion device such that thermal energy is transferred from the cushion device to the enclosure; a temperature sensor disposed within the chamber; and an agitator disposed within the container configured to agitate the biological substance contained within the enclosure.
Opposed cushion device pair defining a chamber with insulating and conductive layers adjacent to the biological enclosure
An enclosure containing a biological substance; a first pair of cushion devices positioned opposite each other and defining a chamber therebetween, wherein the enclosure is positioned within the chamber and each cushion device in the first pair of cushion devices comprises a heating element configured to generate heat in response to receipt of a control signal, a thermally insulating layer positioned on a first side of the heating element, and a thermally conductive layer directly attached to a second side of the heating element opposite the thermally insulating layer, wherein the thermally conductive layer is positioned adjacent to the chamber; a temperature sensor disposed within the chamber; and an agitator configured to agitate the biological substance contained within the enclosure.
Opposed first and second heat-conducting cushion devices transferring thermal energy to an enclosure
A container comprising a chamber; a first cushion device disposed within the chamber with a first heat conducting layer directly attached to a first heating element configured to generate thermal energy; a second cushion device disposed within the chamber and positioned opposite the first cushion device with a second heat conducting layer directly attached to a second heating element configured to generate thermal energy; an enclosure containing a biological substance configured to be positioned within the chamber between the first and second cushion devices such that thermal energy is transferred from the first and second cushion devices to the enclosure; a temperature sensor disposed within the chamber; and an agitator disposed within the chamber configured to agitate the biological substance contained within the enclosure.
The independent claims collectively cover modular dry thawing apparatuses that transfer thermal energy from cushion devices to an enclosure containing biological substances within a chamber, while including a temperature sensor and an agitator. The core structural differences across independent claims are the arrangement of cushion devices as a single cushion device on one side of the chamber, an opposed first pair defining a chamber therebetween, or first and second opposed cushion devices transferring energy to the enclosure between them.
Stated Advantages
Documented Applications
No documented applications found
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