Nutritional compositions containing a prebiotic and lactoferrin and uses thereof
Inventors
Chichlowski, Maciej • Berg, Brian • Jouni, Zeina • Wittke, Anja • Waworuntu, Rosaline
Assignees
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Publication Number
US-10709770-B2
Publication Date
2020-07-14
Expiration Date
Abstract
Provided is a composition and method for modulating serotonergic receptor expression, reducing anxiety-like behavior and stress-induced inflammatory response in a pediatric subject, the method including administering to the pediatric subject a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides. Further provided is a method for reducing constipation in a pediatric subject by providing a nutritional composition including lactoferrin from a non-human source and a prebiotic composition including polydextrose and/or galactooligosaccharides.
Core Innovation
The disclosure provides pediatric nutritional compositions that include lactoferrin from a non-human source combined with a prebiotic composition comprising polydextrose and a galacto-oligosaccharide. The compositions further include a source of long chain polyunsaturated fatty acids and specified fat or lipid sources, including milk fat globules derived from an enriched lipid fraction of bovine milk, together with specified preservatives.
The nutritional compositions are described as resulting in increased serotonergic receptor expression in a pediatric subject, including increased 5-HT1a receptor expression. The disclosure further describes that the compositions promote beneficial gut microbiota, including increased Lactobacillus and Bifidobacterium, without adding probiotics.
The compositions are also described as reducing constipation in a pediatric subject and as reducing stress-induced inflammatory responses, including reduced plasma Hsp70/Hsp72 responses. The disclosure is supported by figures and examples including animal studies and a pediatric randomized controlled trial assessing constipation outcomes after prolonged intake of a formula containing PDX/GOS plus other fortified components.
Claims Coverage
The partial content includes two independent claims. Each independent claim focuses on a different pediatric outcome achieved by administering, or providing, a specifically defined nutritional composition comprising non-human lactoferrin, a polydextrose plus galacto-oligosaccharide prebiotic composition, a long chain polyunsaturated fatty acid source, specified fat/lipid components derived from bovine milk, and specified preservatives.
Increasing serotonergic receptor expression by pediatric nutritional composition
A method for increasing serotonergic receptor expression in a pediatric subject by administering a nutritional composition comprising milk fat globules derived from an enriched lipid fraction of bovine milk, lactoferrin from a non-human source, a prebiotic composition comprising polydextrose and a galacto-oligosaccharide, a source of long chain polyunsaturated fatty acids, and a preservative comprising specified benzoate/sorbate salts or calcium disodium EDTA, wherein administration results in increased serotonergic receptor expression.
Reducing constipation by pediatric nutritional composition
A nutritional composition for reducing constipation in a pediatric subject comprising milk fat globules derived from an enriched lipid fraction from bovine milk, a protein source, lactoferrin from a non-human source, a prebiotic composition comprising polydextrose and galactooligosaccharide, a source of long chain polyunsaturated fatty acids comprising docosahexaenoic acid and arachidonic acid and combinations thereof, and a preservative comprising specified benzoate/sorbate salts or calcium disodium EDTA, wherein upon administration the pediatric subject experiences reduction in constipation.
Across the independent claims shown, the inventive core is the use of a pediatric nutritional composition that combines non-human lactoferrin with a polydextrose/galacto-oligosaccharide prebiotic composition, a defined long chain polyunsaturated fatty acid source, and specified bovine-derived milk fat globule lipid components with specified preservatives, to achieve either increased serotonergic receptor expression or reduced constipation.
Stated Advantages
Increased serotonergic receptor expression in a pediatric subject.
Increased 5-HT1a receptor expression.
Promotion of beneficial gut microbiota, including increased Lactobacillus and Bifidobacterium.
Reduction in stress-induced inflammatory responses, including reduced plasma Hsp70/Hsp72 responses.
Reduction in constipation.
Documented Applications
Increasing serotonergic receptor expression in a pediatric subject via administration of the nutritional composition.
Reducing constipation in a pediatric subject via administration of the nutritional composition.
Use in connection with animal studies assessing 5-HT1a mRNA and anxiety-like behavior.
Use in connection with a pediatric randomized controlled trial assessing constipation outcomes after prolonged intake of a formula containing PDX/GOS plus other fortified components.
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