System and method for noninvasive analysis of subcutaneous tissue
Inventors
Cohen, Yaniv • Klein, Ronnie • ZILBERMAN, Arkadi • Dekel, Ben Zion • Blaunstein, Nathan
Assignees
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Publication Number
US-10709365-B2
Publication Date
2020-07-14
Expiration Date
Abstract
A method for noninvasive analysis of subcutaneous tissue includes irradiating a surface of the tissue with short wave infrared (SWIR) radiation in a first spectral band that is strongly absorbed by water, and with SWIR radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical. An intensity of the radiation in each of the spectral bands that emerges from the tissue is measured. A relative absorption by the tissue of radiation in one of spectral bands relative to absorption by the tissue of radiation in the other of the spectral bands is calculated. A state of the tissue is determined in accordance with the calculated relative absorption.
Core Innovation
The invention provides a noninvasive analysis of tissue by irradiating a surface of the tissue with short wave infrared (SWIR) radiation in a first spectral band that is strongly absorbed by water, and with SWIR radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical. The radiation interaction comprises at least one of absorption and scattering. By selecting the two spectral bands to interact substantially identically with tissue components other than water, the analysis can use the difference related to water-absorbing behavior.
The method measures, with at least one radiation detector, an intensity of the radiation that emerges from the tissue in each of the spectral bands, and determines a change in at least one of shape and intensity of signals received by the detector. A processor calculates a relative absorption by the tissue of radiation in one of the first and second spectral bands relative to absorption by the tissue of radiation in the other of the first and second spectral bands. The relative absorption is calculated in accordance with the measured intensity and the determined change in received signal.
The processor determines a subcutaneous deep tissue injury under intact skin in which liquids accumulate subcutaneously, in accordance with the calculated relative absorption and in accordance with the determined change in the received signal. In related embodiments, the approach is implemented in a system having at least one source of infrared radiation, at least one radiation detector to measure intensity in each spectral band, and a processor configured to calculate relative absorption and determine subcutaneous deep tissue injury based on liquids accumulating subcutaneously. The document further includes additional determination for subcutaneous deep tissue injury tied to concentration of a substance in blood within the tissue.
Claims Coverage
The independent claims are directed to a method for noninvasive analysis of tissue using two SWIR spectral bands and relative absorption to determine subcutaneous deep tissue injury under intact skin, and to a corresponding system that performs the same spectral-band irradiation, emergent intensity measurement, relative absorption calculation, and injury determination. A further independent claim specifies a method variant for determining deep tissue injury with a constrained wavelength range for the first spectral band.
Two-band SWIR irradiation with substantially identical non-water interaction
Irradiating a surface of the tissue with SWIR radiation in a first spectral band that is strongly absorbed by water, and with SWIR radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical.
Emergent intensity measurement in both SWIR spectral bands
Measuring an intensity of the radiation that emerges from the tissue in each of the spectral bands with at least one radiation detector, where the interaction comprises at least one of absorption and scattering.
Relative absorption calculation between the spectral bands
Calculating a relative absorption by the tissue of radiation in one of the first and second spectral bands relative to absorption by the tissue of radiation in the other of the first and second spectral bands, and determining change in at least one of shape and intensity of signals received by the detector.
Determine subcutaneous deep tissue injury from liquids accumulating under intact skin
Determining, by a processor, a subcutaneous deep tissue injury under intact skin in which liquids accumulate subcutaneously in accordance with the calculated relative absorption and in accordance with the determined change in the received signal.
System configuration for two-band irradiation, detector measurement, and injury determination
Providing at least one source of infrared radiation including SWIR radiation in the first spectral band strongly absorbed by water and in the second spectral band with substantially identical interaction for a tissue component other than water; at least one radiation detector to measure an intensity of radiation in each spectral band that emerges from the tissue; and a processor configured to calculate a relative absorption by the tissue of radiation in one spectral band relative to absorption in the other spectral band and determine subcutaneous deep tissue injury under intact skin where liquids accumulate subcutaneously in accordance with the calculated relative absorption, wherein the interaction comprises at least one of absorption and scattering.
Wavelength-range constrained two-band method for deep tissue injury
Irradiating with SWIR radiation in a first spectral band in the wavelength range 1300 nm to 1430 nm and in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical; measuring an intensity of the radiation that emerges from the tissue in each spectral band; calculating a relative absorption by the tissue of radiation in the two spectral bands; and determining a subcutaneous deep tissue injury under intact skin in which liquids accumulate subcutaneously in accordance with the calculated relative absorption, wherein the interaction comprises at least one of absorption and scattering.
Across the independent claims, the core inventive scheme is based on two SWIR spectral bands selected so non-water tissue components interact substantially identically, measurement of emergent intensity in each band, computation of relative absorption between the bands, and determination of subcutaneous deep tissue injury under intact skin where liquids accumulate.
Stated Advantages
Noninvasive analysis of tissue.
Determination of subcutaneous deep tissue injury under intact skin in which liquids accumulate subcutaneously.
Calculation of relative absorption by the tissue using substantially identical interaction of tissue components other than water across two SWIR spectral bands.
Injury-related determination can be supported by concentration of a substance in blood within the tissue.
Documented Applications
Determining a subcutaneous deep tissue injury under intact skin in which liquids accumulate subcutaneously (including supporting determination tied to concentration of a substance in blood within the tissue).
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