Devices and methods for delivering a lyophilized medicament
Inventors
Blondino, Frank E. • Edwards, Eric S. • Edwards, Evan T. • Meyers, Paul F.
Assignees
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Publication Number
US-10695495-B2
Publication Date
2020-06-30
Expiration Date
Abstract
An apparatus includes a housing, an actuator, a lock mechanism, and a medicament container. The lock mechanism selectively engages a portion of the housing such that (1) the lock mechanism is maintained in a substantially fixed position when the housing is in a first orientation and (2) the lock mechanism is removable from the housing when the housing is in a second orientation. The medicament container is moved in a proximal direction when the lock mechanism is removed from the housing to mix a first medicament portion contained within the medicament container with a second medicament portion contained within the medicament container. The actuator can be moved from a first position to a second position when the lock mechanism is removed from the housing to release energy stored within an energy storage member such that the medicament container is moved in a distal direction.
Core Innovation
The invention relates to medicament delivery devices for delivering lyophilized medicament contents using orientation-dependent safety and lock mechanisms. A medicament container is housed in a housing, and a safety member is movable relative to the housing between a first position and a second position, where the safety member limits delivery by placing a lock protrusion within a lock chamber to cooperate with a lock member.
A lock member disposed within the lock chamber moves along a housing surface when an orientation of a longitudinal axis changes. The lock member is positioned in contact with the lock protrusion to limit movement of the safety member from the first position to the second position when the longitudinal axis is in a first orientation, and the lock member is spaced apart from the lock protrusion when the longitudinal axis is in a second orientation. The safety member is removed from the housing when the safety member is in the second position.
The invention further uses an energy storage member that produces a force to convey contents from the medicament container when actuated by movement of the safety member. The contents include gas, and the medicament container is described with first and second elastomeric members defining a first volume and a second volume containing the gas. Optional mixing functionality is supported by a mixing protrusion driven by stored force to drive mixing and convey medicament contents onto an elastomeric member, with additional orientation-responsive lock-chamber geometry that guides the lock-member engagement.
Claims Coverage
The independent claims identified are clm-00001, clm-00012, and clm-00019. Across these claims, the inventive subject matter centers on an orientation-dependent safety member and lock member cooperation, and on coupling that orientation-responsive safety actuation to energy-storage-driven conveyance of medicament contents including gas, with further features such as multiple lock protrusions and, in one claim family, injector/needle-sheath handling.
Orientation-dependent safety member lock-chamber engagement with removable safety member
A housing defines a lock chamber, a safety member is moved between first and second positions to limit delivery, and a lock protrusion of the safety member is disposed within the lock chamber in the first position and disposed outside the lock chamber in the second position. A lock member in the lock chamber moves along a housing surface when the orientation of a longitudinal axis changes, contacting the lock protrusion in a first orientation to limit safety-member movement and spacing apart in a second orientation, wherein the safety member is removed from the housing when in the second position.
Elastomeric multi-volume medicament container with gas-containing second volume and orientation-actuated energy storage member
A medicament container includes a first elastomeric member in a proximal portion defining at least part of a first volume containing a first substance and a second elastomeric member disposed distally defining a second volume containing a second substance. A housing contains an energy storage member configured to produce force to convey contents when actuated, where the contents include gas from the second volume. A safety member coupled to the housing actuates the energy storage member when moved between first and second positions and engages a lock member to limit movement from the first position to the second position when a longitudinal axis is in a first orientation, with the second portion of the safety member spaced apart from the lock member when the longitudinal axis is in a second orientation.
Safety member actuates energy storage to convey medicament contents with plurality of lock protrusions and orientation-based spacing
A safety member coupled to a housing moves between first and second positions, with a lock portion disposed within a lock chamber in the first position and engaging a lock member to limit movement from the first position to the second position when a longitudinal axis is in a first orientation. The lock portion is spaced apart from the lock member when the longitudinal axis is in a second orientation, and an actuation portion actuates an energy storage member to produce force to convey contents from a medicament container when actuated. The lock portion includes a plurality of lock protrusions configured to be disposed through corresponding openings from a plurality of openings in the housing within the lock chamber in the first position, wherein the plurality of lock protrusions collectively define a volume in which the lock member is disposed when the safety member is in the first position and the longitudinal axis is in the first orientation.
Across the independent claims, the core claim coverage is directed to an orientation-dependent mechanism in which a safety member and lock protrusion cooperate with a lock member inside a lock chamber to permit or limit safety-member movement based on longitudinal-axis orientation. In parallel with this safety and locking function, the safety-member movement actuates an energy storage member that produces force to convey medicament contents, including gas associated with defined elastomeric container volumes, and in one independent claim includes multiple lock protrusions through corresponding housing openings to establish a defined lock-member volume.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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