Biomaterials suitable for use as drug eluting, magnetic resonance imaging detectable implants for vascular occlusion
Inventors
Reb, Philippe • Chaix, Celine • Thomas, Meriadeg
Assignees
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Publication Number
US-10695440-B2
Publication Date
2020-06-30
Expiration Date
Abstract
Biomaterials suitable for use as drug eluting, Magnetic Resonance Imaging (“MRI”) detectable implants for vascular occlusion are provided, as are methods of producing such biomaterials. Further, methods of treating an individual suffering from a solid tumor are provided.
Core Innovation
The invention provides a biomaterial suitable for use as a drug eluting, Magnetic Resonance Imaging (“MRI”) detectable implant for vascular occlusion. The biomaterial comprises a copolymer including N-[tris-(hydroxymethyl)methyl] acrylamide together with vinyl sulfonate or 2-carboxyethyl acrylate (“CEA”), an iron oxide particle, and a drug.
The biomaterial is designed to releasably associate the drug with the microsphere and to support treatment of solid tumors through vascular occlusion and drug delivery. The document further characterizes the biomaterial in terms of physical form, including substantially spherical microspheres, and includes MRI guidance and/or confirmation concepts.
The stated problem is providing a drug eluting implant that is MRI detectable and suitable for vascular occlusion to treat disease settings such as solid tumors, including hepatic tumor contexts as described. By incorporating an iron oxide particle into the implant and associating a drug that releasably associates with microspheres, the invention combines vascular occlusion with MRI detectability and drug delivery within a single biomaterial implant.
Claims Coverage
Two independent claims are identified. The claims focus on an MRI-detectable, drug-eluting vascular occlusion implant defined by a specific copolymer, an iron oxide particle, and a drug.
Drug eluting MRI detectable vascular occlusion biomaterial implant
A biomaterial suitable for use as a drug eluting, Magnetic Resonance Imaging (“MRI”) detectable implant for vascular occlusion, comprising a copolymer, an iron oxide particle, and a drug.
N-[tris-(hydroxymethyl)methyl] acrylamide and vinyl sulfonate copolymer with iron oxide and drug
A copolymer comprising N-[tris-(hydroxymethyl)methyl] acrylamide and vinyl sulfonate, an iron oxide particle, and a drug.
N-[tris-(hydroxymethyl)methyl] acrylamide and 2-carboxyethyl acrylate (CEA) copolymer with iron oxide and drug
A copolymer comprising N-[tris-(hydroxymethyl)methyl] acrylamide and 2-carboxyethyl acrylate (“CEA”), an iron oxide particle, and a drug.
The inventive coverage centers on a biomaterial implant for vascular occlusion that is drug eluting and MRI detectable, defined by a copolymer specified by N-[tris-(hydroxymethyl)methyl] acrylamide with either vinyl sulfonate or CEA, an iron oxide particle, and a drug.
Stated Advantages
Provides a drug eluting implant that is Magnetic Resonance Imaging (“MRI”) detectable for vascular occlusion.
Enables vascular occlusion together with drug elution using the specified copolymer and iron oxide particle combination.
Documented Applications
Solid tumor treatment by administering the implant to occlude tumor-associated vessels and deliver chemotherapy with MRI guidance/confirmation, including mention of hepatic tumor.
Use of MRI guidance and/or confirmation in association with delivering a vascular occlusion implant that elutes chemotherapeutic drugs.
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