Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
Inventors
Benk, Christoph • Beyersdorf, Friedhelm • Trummer, Georg
Assignees
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Publication Number
US-10695407-B2
Publication Date
2020-06-30
Expiration Date
Abstract
The present invention relates to a protective solution for preventing or reducing reperfusion injury of the brain which contains magnesium ions and which has an osmolality of 350 to 600 mOsm/L, a pH value of 6.8 to 7.8 and albumin in an amount of 1 to 20% by weight.
Core Innovation
The invention relates to a protective “priming” solution for use during cardiopulmonary resuscitation to prevent and/or reduce whole-body and especially brain ischemia-reperfusion injury. The document describes administration of a protective solution intended to protect the brain during the reperfusion period following cardiopulmonary resuscitation.
The protective solution comprises magnesium ions and albumin in an amount of 1 to 20% by weight. The solution is further defined by an osmolality of 440 to 550 mOsm/L and a pH value of 7.5 to 7.8.
The document also discusses related formulation components and attributes, including optional mannitol, citrate for calcium chelation, lidocaine, heparin, optional potassium, norepinephrine, and cyclosporin A, as well as low viscosity. The provided example describes use in an animal model of ventricular fibrillation with improved neurologic recovery and reduced mortality and brain damage compared with Ringer control under delayed resuscitation conditions, with optional hypothermia further improving outcomes.
Claims Coverage
The document includes two independent claims. The first defines a protective solution with magnesium ions, albumin, specified osmolality, and pH, and the second defines a method using that protective solution after cardiopulmonary resuscitation to reduce brain reperfusion injury; dependent claims further refine formulation options and concentration constraints.
Magnesium ions and albumin protective brain reperfusion-injury solution with defined osmolality and pH
A protective solution for reducing reperfusion injury of the brain comprising magnesium ions and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 440 to 550 mOsm/L and a pH value of 7.5 to 7.8.
Method for reducing brain reperfusion injury after cardiopulmonary resuscitation using a magnesium-albumin protective solution
A method for reducing reperfusion injury of the brain after cardiopulmonary resuscitation comprising administering a protective solution comprising magnesium ions and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 440 to 550 mOsm/L and a pH value of 7.5 to 7.8.
Across the independent claims, the core inventive concept is the use of a magnesium ions and albumin protective solution defined by an albumin amount of 1 to 20% by weight plus specified osmolality and pH, with a method claim applying this protective solution after cardiopulmonary resuscitation to reduce brain reperfusion injury.
Stated Advantages
Reduces reperfusion injury of the brain during cardiopulmonary resuscitation.
Improves neurologic recovery in the provided animal model.
Reduces mortality and brain damage in the provided animal model when compared with Ringer control under delayed resuscitation conditions.
Documented Applications
Protective “priming” solution for use during cardiopulmonary resuscitation to prevent and/or reduce whole-body and especially brain ischemia-reperfusion injury, including an animal model of pig ventricular fibrillation with delayed resuscitation and neurologic outcome assessment.
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