Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Assignees
Member
CrossjectCrossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Crossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Publication Number
US-10675409-B2
Publication Date
2020-06-09
Expiration Date
Abstract
The present disclosure is directed towards a needleless injection device including an injection system which includes at least one injection nozzle which delimits at least one injection channel, and which is axially delimited by an upper face arranged facing the lower face of the reservoir, and a lower face adapted to cooperate with a cap, and an upper sealing gasket which extends around the at least one channel and which is housed in an upper groove formed on the upper face of the nozzle, and the upper gasket has a wave-shaped radial section which comprises successively, along a radial direction, a recessed portion and a bump portion, said bump portion being adapted to be lying toward the recessed portion provided to this end, under the effect of the axial pressure exerted by the lower face of the reservoir on said sealing gasket.
Core Innovation
The invention relates to a needleless gas-driven injection device having an injection nozzle that defines injection channels extending axially along an injection axis. The injection nozzle delimits channels from an upper face to a lower face, and the device includes an active ingredient reservoir with a lower face arranged to cooperate with the nozzle.
An upper sealing gasket extends around the injection channel(s) and is housed in an upper groove formed on the upper face of the nozzle. The upper sealing gasket has a wave-shaped radial section comprising successively a recessed portion and a bump portion, where the bump portion is configured to lie toward the recessed portion under the effect of an axial pressure exerted by the lower face of the reservoir on the upper sealing gasket.
The wave-shaped radial section further includes an oblique flank and a peripheral ramp enabling the bump to lie toward the recessed portion, thereby reducing gasket pinching/creep and improving sealing. The injection nozzle and gasket geometry include bypassing channels to form a generally circular gasket with three lobe regions that correspond to three injection channels.
Claims Coverage
The independent claim coverage shown concerns a needleless injection device with an injection axis, an active ingredient reservoir, an injection nozzle having at least one axially extending injection channel, and an upper sealing gasket in an upper nozzle groove. Three inventive features are identified across the independent coverage, with additional optional features for channel arrangement, material compatibility, and active ingredient selection.
Wave-shaped upper sealing gasket under axial pressure
The upper sealing gasket has a wave-shaped radial section that comprises successively, along a radial direction, a recessed portion and a bump portion, the bump portion being configured to be lying toward the recessed portion, under the effect of an axial pressure exerted by the lower face of the reservoir on the upper sealing gasket.
Peripheral ramp enabling bump to lie toward recessed portion
The upper sealing gasket has a bump portion with an oblique flank forming a peripheral ramp that enables the bump to lie toward the recessed portion under axial pressure from the reservoir.
Lobe bypassing an offset injection channel
The injection channel is offset relative to the injection axis, and the upper sealing gasket forms at least one lobe that bypasses the offset injection channel.
Three evenly distributed channels with three lobes forming circular gasket shape
The nozzle delimits three injection channels evenly angularly distributed about the injection axis, and the upper sealing gasket forms three lobes bypassing the channels to yield a circular gasket shape with three circular portions.
Chemically adhering thermoplastic elastomer upper sealing gasket on polycarbonate nozzle
The upper sealing gasket is made of a thermoplastic elastomer adapted to chemically adhere on the nozzle, and the nozzle is polycarbonate.
Active ingredient selected from listed compounds
The active ingredient in the reservoir is selected from the group consisting of Methotrexate, Adrenaline, Sumatriptan, Hydrocortisone, Naloxone, Midazolam, Apomorphine, Ethylnatrexone bromide, Phytomenadione, Chlorpromazine zydrochloride, Zuclopenthixol acetate, Danaparoid sodium, Enoxaparin sodium, Estradiol cypionate, Medroxyprogesterone acetate, Medroparin calcium, Methylprednisolone acetate, Heparin calcium, Terbutaline.
The claim coverage emphasizes an upper sealing gasket with a wave-shaped recessed portion and bump portion configured to reconfigure under axial pressure toward sealing alignment, including perimeter-ramp or oblique flank geometry and gasket lobe formations that bypass injection channels. Optional coverage includes chemically adhering thermoplastic elastomer on a polycarbonate nozzle and restriction of the active ingredient to a listed group of compounds.
Stated Advantages
Reducing gasket pinching/creep and improving sealing.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?