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Publication Number
US-10675394-B2
Publication Date
2020-06-09
Expiration Date
Abstract
Disclosed is a multiple bag system for fractionating a fluid, including a fluid collecting bag with at least one outlet port; at least first and second sampling bags, each having at least one inlet port and at least one outlet port; and a mechanism for transferring fluid from the fluid collecting bag to the sampling bags. The fluid transfer mechanism includes an acoustic sorter. Also disclosed is a method for fractionating a fluid into fluid products.
Core Innovation
The invention relates to a closed disposable multiple fluid bag system for fractionating a fluid using a fluid collecting bag, first and second sampling bags, and a first means for transferring fluid. The fluid transferring means includes a channel extending along a longitudinal axis, with a cross section defined by a width measured along a first transverse axis and a thickness measured along a second transverse axis perpendicular to the first transverse axis, and the channel width is greater than or equal to the channel thickness.
At least one wall is arranged for receiving an acoustic wave generator, and the channel thickness and the acoustic wave generator are configured to generate a volumetric acoustic standing wave over the thickness of the channel for sorting and fractionating a fluid. The channel has at least one inlet in fluid communication with the channel and at least first and second outlets in fluid communication with the channel, with the first outlet separated from the second outlet on the second transverse axis.
The fluid collecting bag has at least one outlet port fluidly connected to the at least one inlet of the first means for transferring fluid, and the first and second outlets of the first means are fluidly connected to the inlet ports of the first and second sampling bags, respectively. The invention further provides a method for high throughput preparation of fluid products to be used for fluid transfusion, using the closed disposable multiple fluid bag system with volumetric acoustic standing waves and not surface acoustic standing waves.
Claims Coverage
The document provides two independent claims, one system claim and one method claim, centered on acoustic sorting and fractionating using a closed disposable multi-bag arrangement. In total, the inventive features are defined by a closed disposable multiple fluid bag network and a channel-based acoustic transfer arrangement configured to produce volumetric acoustic standing waves over channel thickness, not surface acoustic standing waves, with specific inlet and outlet separation.
Closed disposable multiple fluid bag fractionation with channel acoustic transfer
A closed disposable multiple fluid bag system comprising a fluid collecting bag with at least one outlet port, first and second sampling bags with inlet and outlet ports, and first means for transferring fluid connecting the collecting bag to the sampling bags, where the transfer means uses a channel extending along a longitudinal axis with a width measured along a first transverse axis and a thickness measured along a second transverse axis, and with first and second outlets separated on the second transverse axis and connected to the respective sampling bag inlet ports.
Volumetric acoustic standing waves over channel thickness for sorting and fractionating
The channel thickness and an acoustic wave generator configured to generate an acoustic wave are arranged so that the system generates volumetric acoustic standing waves over the thickness of the channel for sorting and fractionating a fluid, explicitly producing volumetric acoustic standing waves and not surface acoustic standing waves.
High throughput transfusion fluid product preparation with volumetric acoustic standing waves
A method for high throughput preparation of fluid products to be used for fluid transfusion using the closed disposable multiple fluid bag system, including transferring fluid from the fluid collecting bag to first and second sampling bags through channel-based means for transferring fluid, applying an acoustic field inside the channel over the thickness to sort and fractionate, and collecting a first fluid product in the first sampling bag and a second fluid product in the second sampling bag, where the acoustic field contains volumetric acoustic standing waves and not surface acoustic waves.
Across the independent claims, the coverage is concentrated on a closed disposable multiple fluid bag network and a channel-based acoustic transfer arrangement in which an acoustic wave generator is configured to produce volumetric acoustic standing waves over channel thickness, not surface acoustic standing waves, to sort and fractionate fluid into separate sampling bags for transfusion use.
Stated Advantages
High throughput preparation of fluid products to be used for fluid transfusion.
Sorting and fractionating a fluid using volumetric acoustic standing waves inside the channel while explicitly not using surface acoustic standing waves.
Documented Applications
High throughput preparation of fluid products to be used for fluid transfusion, including collecting first and second fluid products in separate sampling bags.
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