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Assignees
Member
CrossjectCrossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Crossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Publication Number
US-10653839-B2
Publication Date
2020-05-19
Expiration Date
Abstract
The present disclosure concerns a needleless injection device including a body forming a housing, a gas generator, a tubular reservoir which contains an active ingredient to be injected, and a generally T-shaped elastically deformable membrane. The membrane includes a tubular portion which extends axially in the reservoir and is designed to lie axially in the reservoir under the effect of the pressure generated by the gas generator. A nozzle for injecting the active ingredient is arranged at the lower end of the reservoir. The device further includes a sock which wraps the tubular portion of the membrane, at least partially. The sock is adapted to limit the friction between the tubular portion of the membrane and the reservoir.
Core Innovation
The invention relates to a needleless injection device driven by a gas generator. A body forming a housing accommodates the gas generator and a tubular reservoir that contains an active ingredient to be injected, and the tubular reservoir extends axially in the housing from an upper end to a lower end with an injection nozzle arranged at the lower end.
A generally T-shaped elastically deformable membrane comprises a tubular portion configured to extend and lie axially in the tubular reservoir under the effect of pressure generated by the gas generator. To limit friction between the tubular portion of the membrane and the tubular reservoir, a sock at least partially wraps the tubular portion and is configured to reduce friction and provide low-friction sliding.
The sock is described as being slidably mounted with a smaller diameter than the reservoir inner wall and as being rigid to resist radial deformation. The friction limiting between the membrane tubular portion and the tubular reservoir is associated with limiting absorbed energy and improving jet pressure and membrane deployment/elongation.
Claims Coverage
The independent claim covers 3 inventive features: a gas-generator-driven needleless injection device with a tubular reservoir and injection nozzle, a T-shaped elastically deformable membrane with an axially extending tubular portion under gas-generated pressure, and a sock that wraps the membrane tubular portion to limit friction with the tubular reservoir.
Needleless injection device with gas generator and tubular reservoir
A needleless injection device including a body forming a housing, a gas generator, a tubular reservoir that contains an active ingredient to be injected and extends axially in the housing from an upper end to a lower end, and an injection nozzle arranged at the lower end of the tubular reservoir.
T-shaped elastically deformable membrane with axial tubular portion under gas pressure
A T-shaped elastically deformable membrane comprising a tubular portion configured to extend and lie axially in the tubular reservoir under an effect of a pressure generated by the gas generator.
Sock wrapping the membrane tubular portion to limit friction
A sock that at least partially wraps the tubular portion of the membrane and is adapted to limit friction between the tubular portion of the membrane and the tubular reservoir.
The coverage centers on a gas-generator-driven needleless injection device with an axially acting, T-shaped elastically deformable membrane and a sock that wraps the membrane’s tubular portion to limit friction with the tubular reservoir.
Stated Advantages
Limits absorbed energy.
Improves jet pressure.
Improves membrane deployment/elongation.
Documented Applications
Needleless injection for an active ingredient selected from the listed drugs, including Methotrexate, Adrenaline, Sumatriptan, Hydrocortisone, Naloxone, Midazolam, Apomorphine, Ethylnatrexone bromide, Phytomenadione, Chlorpromazine hydrochloride, Zuclopenthixol acetate, Danaparoid sodium, Enoxaparin sodium, Estradiol cypionate, Medoxyprogesterone acetate, Medroparin calcium, Methylprednisolone acetate, Heparin calcium, and Terbulin.
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