Pediatric nutritional composition with milk peptides for healthy growth and development
Inventors
Banavara, Dattatreya • Batema, Roseanne P.
Assignees
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Publication Number
US-10639334-B2
Publication Date
2020-05-05
Expiration Date
Abstract
The present disclosure generally provides pediatric nutritional compositions comprising a protein source comprising an intact milk protein and a partially hydrolyzed milk protein, wherein about 5% to about 25% of total nitrogen content of the composition is non-protein nitrogen. The pediatric nutritional compositions described herein also comprise a fat source and a carbohydrate source. The partially hydrolyzed protein source, in certain embodiments, provides peptides that have similar structure and function to the peptides found in human milk.
Core Innovation
A pediatric nutritional composition is provided that includes a protein source with an intact milk protein and a partially hydrolyzed milk protein. The intact milk protein comprises whey and casein, and the partially hydrolyzed milk protein comprises peptides having a molecular weight of less than 10 kDa. The composition is configured so that the non-protein nitrogen is provided by the partially hydrolyzed milk protein and so that the peptide profile mimics human milk nitrogen and peptide profiles.
The partially hydrolyzed milk protein includes individual peptides derived from β-lactoglobulin, with selected peptide sets identified by SEQ ID Nos. 1-9 as core peptides and SEQ ID Nos. 10-53 as functional peptides. The peptide profile is characterized by targeted molecular-weight ranges, including <10 kDa and predominantly <5 kDa, and by stated functional structure/function consistent with human milk peptide activities.
The composition is stated to provide multiple biological activities associated with milk peptides, including antioxidant, antimicrobial, antiviral, and immunomodulatory activity, and ACE inhibitory activity. The document further describes reducing β-lactoglobulin allergen content and supporting milk peptide tolerance, with optional formulation context including fat and carbohydrate sources and optional additives such as probiotics, prebiotics, DHA, β-glucan, lactoferrin, and choline.
Claims Coverage
The independent claim provides 1 core claim with several dependent refinements. The inventive features focus on the combination of intact milk protein and a partially hydrolyzed milk protein with <10 kDa peptides, defined whey-to-casein ratio and quantitative per-100 kcal protein amounts, and specific peptide identity and quantitative property constraints that further specify peptide profile and functional endpoints.
Intact milk protein plus partially hydrolyzed <10 kDa peptides
A nutritional composition comprising a protein source including an intact milk protein and a partially hydrolyzed milk protein comprising peptides having a molecular weight of less than 10 kDa, with defined intact milk protein and <10 kDa peptide amounts per 100 kcal.
Defined β-lactoglobulin peptide set in partially hydrolyzed milk protein
The partially hydrolyzed milk protein includes each of the following individual peptides derived from β-lactoglobulin: SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5, and SEQ ID No. 8.
Whey-to-casein ratio for intact milk protein
The intact milk protein comprises whey and casein having a whey to casein weight ratio ranging from about 80:20 to 50:50.
Defined whey and casein protein amounts per 100 kcal
The intact milk protein is present in an amount of from about 1.35 g per 100 kcal to about 2.85 g per 100 kcal and the peptides having a molecular weight of less than 10 kDa are present in an amount of from about 0.09 g per 100 kcal to about 0.75 g per 100 kcal.
Peptide molecular-weight distribution constraint
At least 75% by weight of the peptides have a molecular weight below 5 kDa.
Degree of hydrolysis range
The hydrolyzed milk protein has a degree of hydrolysis ranging from about 4% to about 40%.
Intact protein fraction of total nitrogen
The intact protein comprises about 75% to about 95% of the composition’s total nitrogen content.
Additional peptide sources including signaling and growth proteins
The partially hydrolyzed milk protein includes additional peptides derived from β-casein, β1-S1-casein, κ-casein, β1-lactalbumin, β2-lactoglobulin, IL-2, TGF-β, IGF-1, GLYCAM-1, SDPR protein, in any combination.
Trolox-equivalent antioxidant capacity threshold
The peptides provide at least 5 mM Trolox-equivalent antioxidant capacity.
Overall, the claim set centers on a nutritional composition combining intact whey/casein with partially hydrolyzed milk protein containing <10 kDa peptides, with defined per-100 kcal quantities and a whey-to-casein ratio. The dependent claims further constrain peptide molecular-weight distribution and hydrolysis degree, specify an intact protein nitrogen fraction, expand peptide-source identity coverage to include signaling/growth proteins, and impose a Trolox-equivalent antioxidant capacity threshold.
Stated Advantages
Reduced β-lactoglobulin allergen content.
Provides milk peptide tolerance.
Documented Applications
Pediatric nutritional compositions including infant formula and growing-up milk.
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