Heating unit for use in a drug delivery device
Inventors
Wensley, Martin J. • Glazer, Marc • Bresson, James • Timmons, Ryan • Myers, Daniel J.
Assignees
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Publication Number
US-10625033-B2
Publication Date
2020-04-21
Expiration Date
Abstract
Drug supply units are disclosed which comprise substrates having a plurality of holes formed therein.
Core Innovation
The invention is an aerosol drug delivery device comprising a drug supply unit with a breath actuation component initiated when a user places the device in the mouth and inhales. It includes a substrate with a surface containing formed circular through-holes through which air flows, wherein at least a portion of the surface is coated with a drug composition. The circular through-holes have a diameter at least as great as the substrate thickness.
Heating vaporizes the drug composition, and air flowing across and through the substrate cools the vapor to form a condensation aerosol. Perforated-substrate performance, aerosol purity, and yield depend on airflow and coating parameters, allowing particle size adjustment through the airflow ratio. Reported aerosol purity remains high during storage, and the background problem addressed is not explicitly described in the patent.
Claims Coverage
The supplied claims identify one independent claim that covers two inventive features of an aerosol drug delivery device.
Inhalation-actuated drug supply unit
A drug supply unit comprises a breath actuation component initiated by a user placing the device in the mouth and inhaling, which initiates air flow through the substrate holes.
Drug-coated substrate with circular through-holes
A substrate surface contains a plurality of formed through-holes through which air flows, and at least a portion of the surface is coated with a drug composition, wherein the holes are circular and have a diameter at least as great as the substrate thickness.
The claim combines an inhalation-actuation mechanism with a drug-coated substrate having circular through-holes with diameters at least as great as the substrate thickness.
Stated Advantages
The number and spacing of the holes provide vaporized drug with greater purity than vapor from a substrate without through-holes.
The perforations and airflow improve aerosol purity and drug yield.
The device permits thicker drug coatings.
Particle size can be adjusted through the airflow ratio.
Documented Applications
An aerosol drug delivery device in which a user inhales through a breath actuation component to initiate air flow through the substrate holes.
Inhalation-actuated delivery of a drug composition as a condensation aerosol.
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