Vaporized medicants and methods of use
Inventors
Chong, Alexander ChinHak • Bartkowski, William P • Thompson, Marshall A
Assignees
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Publication Number
US-10610483-B2
Publication Date
2020-04-07
Expiration Date
Abstract
A method and formulation for delivering an active analgesic compound, such as an opiate, in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the active compound. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer.
Core Innovation
The invention relates to delivering medicants through inhalation by acquiring a medicant solution suitable for vaporization and inhalation at a low temperature. The medicant solution includes an excipient comprising an inert non-reactive compound and an analgesic, and the vaporized output provides an effective serving of the analgesic for inhalation by a user. The low temperature is from approximately 90 degrees C. to approximately 280 degrees C., and vaporization is performed using a low temperature vaporizer having a mouthpiece.
A key aspect is using an inert non-reactive excipient carrier to enable low-temperature vaporization while providing inhalation delivery of analgesic medicants. Example inert non-reactive excipients described include propylene glycol, vegetable glycerin, and polysorbates, including polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80. Formulation options include water and/or alcohol, and the analgesic is selected from opiates and opioids.
The disclosure further emphasizes that inhalation delivery provides a faster onset relative to oral delivery while aiming to reduce gastrointestinal side effects and overdose risk. The document supports handheld and portable vaporizer and cartridge or disposable cartridge concepts, together with a rationale for low-temperature operation and metered effective dosing for user inhalation.
Claims Coverage
The document includes two independent claims that cover inhalation delivery of analgesics using a medicant solution with an inert non-reactive excipient, vaporized at a specified low temperature using a low temperature vaporizer. The independent claims collectively emphasize the medicant solution composition, low-temperature vaporization within an approximately 90–280 degrees C. range, and delivery of an effective serving of the analgesic to a user for inhalation, with additional specificity in one claim regarding excipient selection and excipient concentration range.
Low-temperature inhalation delivery of analgesic medicant solution
Acquiring a medicant solution suitable for vaporization and inhalation at a low temperature, wherein the medicant solution includes an excipient comprising an inert non-reactive compound and an analgesic selected from opiates and opioids, and vaporizing the medicant solution at the low temperature such that an effective serving of the analgesic is provided to the user for inhalation, wherein the low temperature is from approximately 90 degrees C. to approximately 280 degrees C.
Low temperature vaporizer having a mouthpiece
Vaporizing the medicant solution comprises using a low temperature vaporizer having a mouthpiece.
Inert excipient selection and concentration range for inhalation delivery
Acquiring a medicant solution suitable for vaporization and inhalation at a low temperature, wherein the medicant solution includes an excipient comprising an inert non-reactive compound selected from polysorbate, propylene glycol, and glycerin, and the inert non-reactive compound is present at a concentration of about 1 percent to about 100 percent of the excipient; vaporizing the medicant solution at the low temperature such that an effective serving of the analgesic is provided to the user for inhalation, wherein the low temperature is from approximately 90 degrees C. to approximately 280 degrees C.
Overall, the independent claims cover a method of delivering analgesics via inhalation by vaporizing a medicant solution at approximately 90–280 degrees C., using an inert non-reactive excipient and providing an effective serving to the user. One claim further requires a low temperature vaporizer having a mouthpiece, while another further restricts the inert excipient choices to polysorbate, propylene glycol, and glycerin and limits the inert non-reactive compound concentration to about 1% to about 100% of the excipient.
Stated Advantages
Faster onset with inhalation versus oral delivery.
Reduced gastrointestinal side effects.
Reduced overdose risk.
Documented Applications
Inhalation delivery of analgesic medicants, including opiates and opioids, using a low temperature vaporizer for user administration with an effective serving dose.
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