Nutritional compositions and methods for promoting cognitive development
Inventors
Ao, Zihua • Berseth, Carol Lynn • Cobb, Patricia • Gonzalez, Juan M. • London, Elisha • Nguyen, Minhthy • Richards, James David • Rudolph, Colin • Alvey, John D. • Maldonado, Yadilka • Kuang, Chenzhong • Xiao, Yan • Hondmann, Dirk
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-10582714-B2
Publication Date
2020-03-10
Expiration Date
Abstract
A method for enhancing cognitive development in a pediatric subject involving administering to the subject a nutritional composition which includes up to 7 g/100 Kcal of a fat or lipid; up to 5 g/100 Kcal of a protein or protein equivalent source; 0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk; 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acid; and 0.015 g/100 Kcal to 1.5 g/100 Kcal of a prebiotic.
Core Innovation
The invention is a method for supporting functional neuronal maturation in a pediatric subject by administering a nutritional composition. The nutritional composition includes buttermilk and buttermilk components, a source of long chain polyunsaturated fatty acid comprising docosahexaenoic acid, a prebiotic, and lactoferrin, together with additional macronutrient constraints.
The method uses buttermilk as an ingredient providing phospholipids, sphingomyelin, and gangliosides. The buttermilk comprises defined amounts of phospholipids, sphingomyelin, and gangliosides per unit energy, and the nutritional composition further specifies defined amounts of fat or lipid and protein source per unit energy.
In addition to buttermilk and prebiotic components, the nutritional composition includes a source of long chain polyunsaturated fatty acid comprising docosahexaenoic acid and lactoferrin. The disclosed embodiments also provide formulation context including milk fat globule membrane components such as phospholipids, sphingomyelin, and gangliosides.
Claims Coverage
The claims are directed to one independent claim for supporting functional neuronal maturation in a pediatric subject via administration of a nutritional composition with defined ingredient categories and quantitative ranges. The independent claim contains five inventive features: buttermilk composition-based lipid fractions, a long chain polyunsaturated fatty acid source with docosahexaenoic acid, a prebiotic, lactoferrin, and macronutrient upper bounds for fat/lipid and protein source.
Supporting functional neuronal maturation via a defined pediatric nutritional composition
Administering to a pediatric subject a nutritional composition comprising up to 7 g/100 Kcal of a fat or lipid, up to 5 g/100 Kcal of a protein source, 0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk, 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acid comprising docosahexaenoic acid, 0.015 g/100 Kcal to 1.5 g/100 Kcal of a prebiotic, and 5 mg/100 Kcal to 300 mg/100 Kcal of lactoferrin.
Buttermilk providing phospholipids, sphingomyelin, and gangliosides
Including buttermilk at 0.25 g/100 Kcal to 16 g/100 Kcal, wherein the buttermilk comprises 6 mg/100 Kcal to 300 mg/100 Kcal of phospholipids, 1 mg/100 Kcal to 60 mg/100 Kcal of sphingomyelin, and 0.25 mg/100 Kcal to 7.5 mg/100 Kcal of gangliosides.
Long chain polyunsaturated fatty acid source comprising docosahexaenoic acid
Providing 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acid, wherein the source comprises docosahexaenoic acid.
Prebiotic component at defined level
Providing 0.015 g/100 Kcal to 1.5 g/100 Kcal of a prebiotic.
Lactoferrin inclusion at defined level
Providing 5 mg/100 Kcal to 300 mg/100 Kcal of lactoferrin.
Overall, the independent claim coverage centers on a pediatric method for supporting functional neuronal maturation using a nutritional composition combining quantified buttermilk-derived phospholipids, sphingomyelin, and gangliosides, a quantified long chain polyunsaturated fatty acid source comprising docosahexaenoic acid, a quantified prebiotic, lactoferrin, and macronutrient upper bounds for fat/lipid and protein source.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?