Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance
Inventors
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Assignees
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FreMon ScientificFreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
FreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
Publication Number
US-10576190-B2
Publication Date
2020-03-03
Expiration Date
Abstract
The present technology discloses a cost-effective, single use bag or container for storing biological substances that incorporates on its inner wall an electronic device that is configured to measure physiological and/or physical parameters of the enclosed biological substances, such as source history, identification, demographics, time stamping, temperature, pH, conductivity, glucose, O2, CO2 levels etc. The electronic device of the disclosed bag comprises a sensor configured to measure physiological and/or physical parameters of the biological substances enclosed within the bag, and a radio-frequency (RF) device communicably coupled to the sensor and configured to: (a) acquire from the sensor data associated with the measured parameters, (b) store the acquired sensor data in nonvolatile memory, and (c) communicate the stored data wirelessly to a RF reader.
Core Innovation
The disclosure relates to a single-use reversibly sealable smart bag, smart label, or overwrap bag concept for storing a biological substance while measuring physiological and/or physical parameters. Sensor data is stored in nonvolatile memory and wirelessly communicated to an RF reader for interrogation. The device architecture includes sensors integrated with an RFID/RF device in a packaged enclosure.
The disclosure also addresses thawing a biological substance using a device with a reversibly sealable housing defining a chamber and containing a plurality of cushion devices. Each cushion device includes a heating element configured to generate thermal energy and a temperature sensor, with thermal management features that position sensors relative to the biological-substance enclosure. The housing is described as hermetic packaging and as supporting a modular chamber configuration.
The disclosure further provides dry thawing concepts that include mechanical agitation and closed-loop thermal regulation. A sonic vibrator assembly provides low-frequency agitation while thermal insulation and flexible layers are described to affect thermal communication between heating and sensing. A central controller regulates heating based on sensed bag temperature and supports reading RFID tags in interrogation zones.
Claims Coverage
The partial content identifies two independent claims (clm-00001 and clm-00014). Across these claims, the core inventive features focus on a reversibly sealable housing defining a chamber with multiple cushion devices that each include a heating element and a temperature sensor, with the temperature sensor positioned relative to an enclosure containing the biological substance.
Reversibly sealable housing with chamber and cushion devices for thawing
A device for thawing a biological substance comprises a reversibly sealable housing defining a chamber, wherein the housing comprises a plurality of cushion devices.
Heating element with flexible layer directly contacting the heating element
Each cushion device comprises a heating element configured to generate thermal energy and a flexible first layer in direct contact with the heating element.
Temperature sensor for thawing adjacent to the enclosure
Each cushion device comprises a temperature sensor positioned to be adjacent to the enclosure containing the biological substance to be thawed when the enclosure is received within the chamber.
Cushion device cushion coupled heating element and adjacent temperature sensing
Each cushion device comprises a cushion, a heating element coupled to the cushion and configured to generate thermal energy, and a temperature sensor positioned to be adjacent to the enclosure containing the biological substance to be thawed.
In the identified independent claims, the thawing device is centered on a reversibly sealable housing/chamber that receives an enclosure containing the biological substance, with multiple cushion devices providing thermal energy via heating elements and sensing via temperature sensors positioned relative to the enclosure.
Stated Advantages
Reduced contamination risk as compared with water baths.
Uniform thawing to reduce overheating/underheating/denaturation.
Low maintenance.
Documented Applications
Thawing a biological substance in a dry thawing device using a reversibly sealable housing/chamber with cushion devices.
Measuring physiological and/or physical parameters of a stored biological substance using sensors integrated with an RFID/RF device and wirelessly communicating sensor data to an RF reader.
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