Tomatidine, analogs thereof, compositions comprising same, and uses for same
Inventors
Adams, Christopher M. • DYLE, Michael C. • Welsh, Michael
Assignees
University of Iowa Research Foundation UIRF • US Department of Veterans Affairs
Publication Number
US-10576091-B2
Publication Date
2020-03-03
Expiration Date
2033-08-02
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Abstract
In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Core Innovation
The invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing an effective amount of tomatidine or its analogs to an animal in need thereof. The compounds disclosed are selected from tomatidine and analogs thereof, which can promote muscle health, normal muscle function, healthy aging muscles, and treat muscle atrophy. The invention further includes pharmaceutical compositions and kits comprising such compounds, and methods for manufacturing medicaments associated with muscle atrophy or the promotion of muscle health.
The problem being solved arises from the lack of medical therapies to prevent or reverse skeletal muscle atrophy, a condition common in starvation, aging, and various severe illnesses. Muscle atrophy leads to significant morbidity, including weakness and loss of independence. Additionally, obesity linked to high adiposity presents major health problems. There is a need for compounds that can both promote muscle hypertrophy and decrease adiposity effectively and selectively. Prior to this invention, tomatidine's ability to influence these conditions was unknown.
Claims Coverage
The patent contains multiple independent claims focusing on methods of improving muscle-related functions and treating muscle disorders using specific compounds.
Use of specific tomatidine compounds to improve muscle and treat obesity-related conditions
The method involves administering a compound represented by a defined chemical formula (formula E1) or compounds such as α-tomatine to increase muscle quality, specific force, strength, exercise capacity, modulate muscle health, increase muscle force generation, reduce obesity, treat muscle disorders (including sarcopenia), and promote muscle health and function.
Administering compositions with defined concentrations of tomatidine compounds
Using compositions containing not less than specific weight percentages (e.g., 0.14% or 0.28%) of the compound or its pharmaceutically acceptable salt, the composition can be in forms such as solutions, dispersions, emulsions, or animal chow, administered orally with or without preservatives and additional additives such as flavoring agents, coloring agents, or binders.
Application of these methods and compositions to a broad range of animal subjects and dosage forms
Treatments can be applied to various animals including non-human primates, livestock, fish, and birds, via nutraceuticals, animal chow, medicinal food, supplements, and pharmaceutical dosage forms like capsules or tablets, providing effective amounts of α-tomatine or related compounds, with dosages ranging from about 0.05% by weight in compositions to specific mg/kg per day dosages.
The independent claims cover methods of using defined chemical compounds, particularly tomatidine and α-tomatine derivatives, for enhancing muscle performance, reducing obesity, treating muscle disorders, and promoting muscle health across diverse animal species, with various pharmaceutical or nutraceutical compositions and dosage forms specified.
Stated Advantages
Tomatidine and analogs promote muscle hypertrophy, increase muscle strength, and improve exercise capacity.
The compounds decrease adiposity and fat mass effectively.
The invention provides a treatment for muscle atrophy and promotes muscle health, normal function, and healthy aging muscles.
Documented Applications
Treatment of muscle atrophy caused by starvation, aging, neurologic disease, chronic illness, immobilization, genetic or autoimmune diseases, spaceflight, or sarcopenia.
Methods to promote muscle hypertrophy, muscle health, muscle strength, normal muscle function, and healthy aging muscles in mammals including humans.
Reduction of adiposity, obesity, and related metabolic conditions such as type 2 diabetes and fatty liver disease.
Use in various animals including mammals, fish, birds, and domesticated livestock for muscle health and growth.
Pharmaceutical and nutraceutical compositions for administration by multiple routes and in various dosage forms including chow, supplements, and medicines.
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