Coenzyme Q10 solubilizing composition and method for preparing same
Inventors
Chung, Sang Jeon • Kim, Ju Hwan • Kang, Hyo Jin
Assignees
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Publication Number
US-10576044-B2
Publication Date
2020-03-03
Expiration Date
Abstract
The present invention relates to a coenzyme Q10 solubilizing composition and a method for preparing the same. In the coenzyme Q10 solubilizing composition and the method for preparing the same according to the present invention, coenzyme Q10, which is a non-soluble drug, is encapsulated by a micelle containing glycyrrhizic acid or a salt of glycyrrhizic acid, bile acid, and unsaturated fatty acid, thereby improving encapsulation efficiency and improving the solubility of coenzyme Q10 in water. In addition, the mass-production of the composition can be easily achieved through sonication or a microfluidizer, the particle size of the composition encapsulating coenzyme Q10 can be controlled, and the natural substance-based formulation without using ethanol and an organic solvent are possible, so that it is expected that the composition of the present invention can be favorably utilized as a composition for pharmaceuticals, foods, and cosmetics, the composition having ensured stability and almost no toxicity.
Core Innovation
The coenzyme Q10 solubilizing composition encapsulates coenzyme Q10 in a micelle. The micelle comprises glycyrrhizic acid or a salt thereof, a bile acid or a salt thereof, and an unsaturated fatty acid, and the composition is cyclodextrin-free. The encapsulated coenzyme Q10 is described as improving water solubility and encapsulation efficiency.
The unsaturated fatty acid is eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). The formulation is described as a natural-substance-based formulation that avoids ethanol/organic solvents, and the micelle particle size is described as controllable. The composition is described as providing stability and low toxicity.
The document discloses formulation options including optional ascorbic acid and component classes. Quantitative constraints include encapsulated coenzyme Q10 loading, coenzyme Q10 concentration in an aqueous solution, mixing ratios on a weight basis, and micelle particle size in a range of 10–200 nm. Characterization is described using encapsulation efficiency by HPLC, particle size and zeta potential, and stability evaluation such as autoclave stability without precipitation, with particle size retention.
Claims Coverage
The independent claim defines a cyclodextrin-free coenzyme Q10 solubilizing composition in which coenzyme Q10 is encapsulated in a micelle containing glycyrrhizic acid or a salt thereof, a bile acid or a salt thereof, and an unsaturated fatty acid, specifically EPA or DHA. The dependent claims add multiple inventive refinements, including quantitative constraints on loading, concentration, component weight mixing ratios, micelle particle size, and composition form.
Cyclodextrin-free micelle encapsulating coenzyme Q10 with glycyrrhizic acid, bile acid, and unsaturated fatty acid
Coenzyme Q10 is encapsulated in a micelle comprising glycyrrhizic acid or a salt thereof, a bile acid or a salt thereof, and an unsaturated fatty acid; the composition is cyclodextrin-free.
Unsaturated fatty acid as EPA or DHA
The unsaturated fatty acid is eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
Encapsulated coenzyme Q10 loading range
The encapsulated coenzyme Q10 amount ranges from 1 wt% to 50 wt% of the total composition weight.
Aqueous coenzyme Q10 concentration range
Coenzyme Q10 is present at a concentration of 0.05 mg/mL to 3 mg/mL in an aqueous coenzyme Q10 solubilizing composition solution.
Weight mixing ratio of micelle components including coenzyme Q10
A weight mixing ratio of glycyrrhizic acid or salt, bile acid or salt, unsaturated fatty acid, and coenzyme Q10 of 0.1–5:0.1–5:0.1–5:0.1–5.
Micelle particle size range
The coenzyme Q10 solubilizing composition has a particle size of 10 nm to 200 nm.
Cosmetic composition form
The coenzyme Q10 solubilizing composition comprises a cosmetic composition.
Across the claim set, the core coverage is a cyclodextrin-free micelle-based encapsulation of coenzyme Q10 using glycyrrhizic acid or salt plus a bile acid or salt and an EPA- or DHA-type unsaturated fatty acid. Additional dependent features constrain encapsulated coenzyme Q10 loading, aqueous concentration, component weight mixing ratios, and micelle particle size, and further specify at least a cosmetic composition form.
Stated Advantages
Improved water solubility.
Improved encapsulation efficiency.
Stability, including autoclave stability without precipitation with retained particle size.
Low toxicity.
Cyclodextrin-free solubilizing composition.
Natural-substance-based formulation avoiding ethanol/organic solvents.
Documented Applications
A pharmaceutical composition.
A food composition.
A cosmetic composition.
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