Methods of treating muscle cramping and related compositions
Inventors
Bean, Bruce P. • MacKinnon, Donald • MacKinnon, Roderick
Assignees
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Publication Number
US-10568853-B2
Publication Date
2020-02-25
Expiration Date
Abstract
Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
Core Innovation
The invention relates to oral compositions and methods for preventing and/or treating muscle cramping in a subject in need thereof. The compositions comprise capsaicinoid, cinnamaldehyde, a gingerol, and an excipient, with specified concentration ranges for capsaicinoids and gingerol. The described use is directed to muscle cramps including nocturnal cramps, menstrual cramps, and cramps associated with exercise fatigue and neuromuscular irritability.
The content describes activating TRPV1, TRPA1, and/or ASIC channels to improve nerve-muscle recovery. It links gastroesophageal sensory neurons and sensory neuron activation with the treatment of muscle cramping and improved nerve-muscle recovery. The mechanistic rationale further describes sensory neuron activation in vitro and synergy among extracts.
Documented results include example human volunteer EMG results showing rapid and sustained cramp reduction and abolition after ingestion of a TRP-Stim beverage. The same content also describes in vitro sensory neuron activation and synergy among extracts, supporting the use of capsaicin or capsaicinoids, cinnamon oil or cinnamaldehyde, and gingerols in an orally administered liquid composition.
Claims Coverage
The partial claim set includes one independent claim covering orally administering a liquid composition with specified ingredients and concentration ranges for capsaicinoids and gingerol.
Oral liquid composition for treating muscle cramping with capsaicinoid, cinnamaldehyde, gingerol, and excipient
A method of treating muscle cramping in a subject in need thereof comprising orally administering a liquid composition comprising capsaicinoid, cinnamaldehyde, a gingerol, and an excipient, wherein the liquid composition comprises 0.001% to 1% w/w capsaicinoids per weight of the liquid composition or 0.0001-0.01 mgs of total capsaicinoids/mL, and a total of 0.001% to 1% w/w of a gingerol per weight of the liquid composition.
Overall, the inventive coverage centers on an orally administered liquid composition containing capsaicinoids, cinnamaldehyde, and a gingerol with defined capsaicinoid and gingerol concentration ranges, as further refined in dependent claims by specific cramp etiologies, administration timing, a capsaicinoid identity, and specific excipient subcomponent selections.
Stated Advantages
Reduces and/or abolishes muscle cramps as indicated by example human volunteer EMG results.
Improves nerve-muscle recovery by activating TRPV1, TRPA1, and/or ASIC channels.
Provides rapid and sustained cramp reduction and abolition after ingestion of a TRP-Stim beverage.
Documented Applications
Treating muscle cramping by orally administering a TRP-Stim beverage or other liquid composition comprising capsaicinoids, cinnamaldehyde, and gingerols.
Application to cramps including exercise-associated fatigue-related cramps, nocturnal cramps, and menstrual cramps.
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