Method and device for enhancing memory consolidation
Inventors
Le Van Quyen, Michel • CHARPIER, Stéphane • MAHON, Séverine
Assignees
Centre National de la Recherche Scientifique CNRS • Assistance Publique Hopitaux de Paris APHP • Institut National de la Sante et de la Recherche Medicale INSERM • Sorbonne Universite • Institut du Cerveau et de La Moelle Epiniere ICM
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Publication Number
US-10561840-B2
Publication Date
2020-02-18
Expiration Date
Abstract
The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.
Core Innovation
The invention relates to a non-invasive method for enhancing and/or consolidating memory by modulating sleep architecture through a closed-loop control of stimuli during non-REM light sleep. A sleeping cycle of a subject is monitored, and an end of a stage I of a non-REM light sleep state is detected by detection of a negative peak with an amplitude inferior to d75 bcV. A first stimulus is emitted at an onset of stage II of the non-REM light sleep state, and a second stimulus is emitted thereafter.
The method repeats emitting the first stimulus and the second stimulus until an end of stage IV of the non-REM light sleep state. The method then restarts at the onset of a further stage II when that onset is detected, thereby extending slow wave sleep stages and modulating an architecture of the sleeping cycle. The monitoring and stimulating are performed in an adaptive manner based on detection events within the sleeping cycle.
A non-invasive method is disclosed for modulating sleep architecture by improving memory consolidation and/or cognition and/or general well-being. Detecting an end of stage I of a non-REM light sleep state relies on a negative peak criterion with an amplitude inferior to d75 bcV, and stimuli emission is synchronized to stage II onsets and repeated through stage IV. The stimulation modalities are described as sensory, electrical, and/or magnetic, including auditory tones, within a device architecture that performs signal monitoring and stimulus control based on the detected sleep stage transitions.
Claims Coverage
The document includes three independent claims. Across them, the inventive concept is characterized by detecting the end of stage I non-REM light sleep using a negative peak threshold (amplitude inferior to d75 bcV) and emitting first and second stimuli synchronized to stage II onset, repeating through stage IV and restarting at a further stage II onset, implemented either as a method or as a device.
Non-invasive memory-enhancing stimulation synchronized to non-REM stage transitions
A non-invasive method for enhancing and/or consolidating memory comprising monitoring a sleeping cycle, detecting an end of a stage I of a non-REM light sleep state by detection of a negative peak with an amplitude inferior to d75 bcV, emitting a first stimulus at a stage II onset, emitting a second stimulus, repeating emitting the first stimulus and the second stimulus until a stage IV end, and restarting when an onset of a further stage II is detected, thereby extending slow wave sleep stages and modulating an architecture of the sleeping cycle.
Non-invasive sleep-architecture modulation via two stimuli around stage II onsets
A non-invasive method for modulating sleep architecture comprising monitoring a sleeping cycle, detecting an end of stage I of a non-REM light sleep state by detection of a negative peak with an amplitude inferior to d75 bcV, emitting a first stimulus at an onset of stage II, emitting a second stimulus, repeating emitting the first stimulus and the second stimulus until an end of stage IV, and restarting when an onset of a further stage II is detected, thereby improving memory consolidation and/or cognition and/or general well-being.
Device using brain-activity electrodes and a programmable microcontroller to emit synchronized stimuli
A device for implementing a non-invasive method for enhancing and/or consolidating memory or modulating sleep architecture, comprising electrodes for measuring a subject's brain activity, stimulators emitting at least one type of sensory, electrical or magnetic stimulus, and a programmable microcontroller board configured to receive and monitor a brain activity signal, detect an end of stage I by detection of a negative peak with an amplitude inferior to d75 bcV and detection of an onset of stage II, cause the stimulators to emit a first stimulus at stage II detection, cause a second stimulus to be emitted, repeat first and second stimulus emission until an end of stage IV, and repeat steps IV to VI when an onset of stage II is detected.
Across the independent claims, the core coverage is provided by closed-loop detection of a non-REM light sleep transition end using a negative peak criterion, emission of first and second stimuli synchronized to stage II onset and repeated until stage IV end, and restarting at a further stage II onset; the invention is covered both as a method and as a device with brain-activity electrodes and a programmable microcontroller driving sensory, electrical, or magnetic stimulation.
Stated Advantages
Extending slow wave sleep stages and modulating an architecture of the sleeping cycle.
Improving memory consolidation and/or cognition and/or general well-being.
Documented Applications
No documented applications found
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