Biofilm inhibiting compositions enhancing weight gain in livestock
Inventors
Ala'Aldeen, Dlawer • Mahdavi, Jafar • Soultanas, Panos
Assignees
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Publication Number
US-10555531-B2
Publication Date
2020-02-11
Expiration Date
Abstract
A method of enhancing the growth of an anima, as well as treating or preventing antimicrobial infections is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron center such as amino acids or α-hydroxy acids. The compounds are also useful for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.
Core Innovation
The invention relates to antibiotic-free compositions that include one or more Fe(III) compounds represented by Formula I, including salts or hydrates thereof, for reducing enteropathogen load and for inhibiting bacterial biofilm formation. Formula I is an Fe(III) complex in which x is an integer value of 1-2 and y is an integer value of 1-3, and the ligand in the complex is independently a conjugate base of a specified α-hydroxy acid or independently a conjugate base of an amino acid selected from a defined group.
The described compounds are configured to function as an antibiotic-free animal feed product, where the compound is present in an effective amount to reduce enteropathogen load in a mammal or bird. The document identifies use in livestock and aquaculture contexts and includes growth enhancement, improved weight gain, and reduced mortality-adjusted feed conversion ratio.
The document further describes functional anti-biofilm and antimicrobial behavior involving bacterial attachment to surfaces and inhibition of biofilm formation against biofilm-associated bacterial species. It includes Campylobacter, including Campylobacter jejuni, and other bacteria including Pseudomonas aeruginosa, Helicobacter pylori, Escherichia coli, Enteropathogenic Escherichia coli, Uropathogenic Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, and MRSA-associated severe SSTIs.
Claims Coverage
The independent claim set includes one independent claim. The claim coverage centers on an antibiotic-free animal feed product containing Formula I Fe(III) compounds with ligands defined as conjugate bases of selected α-hydroxy acids or selected amino acids, effective to reduce enteropathogen load in a mammal or bird. Dependent claims refine specific Formula I selections, ligand classes, concentration ranges, and functional biofilm inhibition against a defined bacterial panel.
Antibiotic-free animal feed product with Formula I Fe(III) complexes
An antibiotic-free animal feed product comprising one or more compounds represented by Formula I, or a salt or hydrate thereof, where x is 1-2, y is 1-3, and each ligand is independently a conjugate base of a specified α-hydroxy acid or a conjugate base of an amino acid from a defined group.
Effective amount to reduce enteropathogen load in a mammal or bird
The compound is present in an effective amount to reduce enteropathogen load in a mammal or bird.
Biofilm inhibition against defined bacterial species
In dependent embodiments, compounds are effective at inhibiting biofilm formation by specified bacteria species or combinations of those species, including a defined group of bacteria.
Particular Formula I ferric compound selection
Dependent embodiments further characterize the product by selecting particular Formula I compounds, including ferric lactate, ferric citrate, ferric tartrate, and ferric tyrosine.
Overall, the claims cover an antibiotic-free animal feed product containing Fe(III) Formula I complexes with ligands restricted to conjugate bases of specified α-hydroxy acids or specified amino acids, used in an effective amount to reduce enteropathogen load, with dependent claims further narrowing to selected ferric instances and anti-biofilm inhibition against a defined bacterial panel.
Stated Advantages
Reduces enteropathogen load in a mammal or bird.
Enhances growth, including improved weight gain.
Reduces mortality-adjusted feed conversion ratio (MFCR).
Inhibits biofilm formation and reduces biofilm formation and colonization by a broad panel of bacteria.
Provides synergy or potentiation with antibiotics to address antibiotic resistance.
Documented Applications
Antibiotic-free animal feed products for mammals or birds, including livestock and aquaculture contexts.
Growth enhancement in livestock and aquaculture, including improved weight gain and reduced mortality-adjusted feed conversion ratio (MFCR).
Biofilm prevention or disruption to reduce bacterial colonization, including colonization by Campylobacter and other listed bacteria.
Use in cosmetics, medical/pharmaceutical/veterinary contexts, including topical, enteral, parenteral, and dental products, and disinfecting/cleaning formulations and coatings/devices.
Synergy or potentiation with antibiotics for addressing antibiotic resistance.
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