Detection and monitoring using high frequency electrogram analysis
Inventors
Ben-David, Tamir • Granot, Yair • Beker, Amir
Assignees
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Publication Number
US-10548498-B2
Publication Date
2020-02-04
Expiration Date
Abstract
An implantable device for analyzing a high frequency (HF) electrogram signal received from subcutaneous, above-rib pickup locations, the device including an implantable electrode for use inside a living body, and a can for subcutaneous implantation, the can including a signal pickup configured to pick up an electrogram signal including a high frequency (HF) component, a signal filter connected to the signal pickup and configured to measure a high frequency (HF) component from the electrogram signal, and an analyzer for analyzing the HF component of the electrogram signal, wherein the analyzer is configured to analyze at least one time-varying parameter of the HF component of the electrogram signal, and the signal filter is configured to measure the electrogram signal by using a signal picked up from at least two pickup locations which are both subcutaneous and above-rib. Related apparatus and methods are also described.
Core Innovation
The invention relates to an implantable device for analyzing a high frequency (HF) electrogram signal received from subcutaneous, above-rib pickup locations. The device includes an implantable electrode for use inside a living body and a can for subcutaneous implantation, the can comprising a signal pickup configured to pick up an electrogram signal comprising an HF component, a signal filter configured to measure an HF component at a frequency >105 Hz, and an analyzer for analyzing the HF component of the electrogram signal.
The analyzer is configured to analyze at least one time-varying parameter of the HF component of the electrogram signal. Based on said analyzing, the analyzer provides an alert indicating ischemia. The signal filter measures the electrogram signal by using a signal picked up from at least two pickup locations, wherein both pickup locations are subcutaneous and above-rib, including a subcutaneous, above-rib electrode pickup location and a can pickup location.
The disclosed claim scope also specifies additional sensing refinements, including simultaneous analysis of additional signal content and multiple signal relationships. The can-based sensing can include measuring a low frequency component of an electrogram signal, simultaneously analyzing an HF component and a low frequency component, and simultaneously analyzing three voltage potential difference signals defined between the can and two subcutaneous pickup locations and between the two subcutaneous pickup locations.
Additional refinements described in dependent claims include correlation-based gating, comparing time-varying parameter values with prior values under specified heart-rate conditions, and performing analysis during specified cardiac-cycle or breathing-cycle segments.
Claims Coverage
The partial content includes two independent claims, an implantable device and a method. Across these claims, the coverage centers on implantable subcutaneous, above-rib HF electrogram sensing, HF filtering at a frequency >105 Hz, time-varying parameter analysis, and ischemia alerting using signals from at least two subcutaneous above-rib pickup locations including a can pickup location.
Subcutaneous, above-rib HF electrogram device with can-based pickup and HF filtering
An implantable device comprising an implantable electrode and a can for subcutaneous implantation, wherein the can includes a signal pickup configured to pick up an electrogram signal comprising a high frequency (HF) component; a signal filter connected to the signal pickup and configured to measure a high frequency (HF) component at a frequency >105 Hz from the electrogram signal; and an analyzer for analyzing the HF component of the electrogram signal.
Time-varying HF parameter analysis with ischemia alerting
The analyzer is configured to analyze at least one time-varying parameter of the HF component of the electrogram signal and to provide an alert indicating ischemia based on said analyzing.
At least two subcutaneous above-rib pickup locations including can pickup location
The signal filter is configured to measure said electrogram signal by using a signal picked up from at least two pickup locations which are both subcutaneous and above-rib, wherein said two pickup locations comprise a subcutaneous, above-rib electrode pickup location and a can pickup location.
Method for receiving, filtering, and analyzing HF electrogram with ischemia alert
A method for analyzing a high frequency (HF) electrogram signal comprising receiving an electrogram signal from at least two subcutaneous, above-rib pickup locations at a can for subcutaneous, above-rib implantation, the can comprising a signal pickup configured to pick up an electrogram signal comprising a high frequency (HF) component at a frequency >105 Hz; a signal filter connected to the signal pickup and configured to measure a high frequency (HF) component from the electrogram signal; and an analyzer for analyzing the HF component of the electrogram signal.
Analyze time-varying parameter and provide ischemia alert in method
The analyzer is configured to analyze at least one time-varying parameter of the HF component of the electrogram signal, and the method includes picking up said electrogram signal, analyzing said HF component of the electrogram signal, and providing an alert indicating ischemia based on said analyzing.
Using at least two pickup locations including subcutaneous above-rib electrode and can pickup
In the method, the signal filter measures said electrogram signal by using a signal picked up from at least two pickup locations, wherein said two pickup locations comprise a subcutaneous, above-rib electrode pickup location and a can pickup location.
Across both independent claims, the core claim coverage requires implantable subcutaneous above-rib pickup, HF component isolation at a frequency >105 Hz, analysis of time-varying HF parameters, and provision of an alert indicating ischemia, with sensing based on signals received from at least two subcutaneous above-rib pickup locations including a can pickup location.
Stated Advantages
Provides an alert indicating ischemia based on analyzing the HF component of the electrogram signal.
Documented Applications
Implantable analysis of HF electrogram signals for ischemia alerting.
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