Substrate having an electron donating surface with metal particles comprising palladium on said surface

Inventors

Ohrlander, Mattias • Södervall, Billy

Assignees

Bactiguard AB

Abstract

There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

Core Innovation

The invention provides a substrate or substrate-treated object having an electron donating surface. The electron donating surface bears palladium-containing metal particles, where the palladium is present together with at least one additional metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum. The metal particles are present at an amount of about 0.001 to about 8 1g/cm2, and the surface is configured to reproducibly modify surface properties.

The disclosure addresses reproducible modification of surface properties on medical and blood-contact devices using an electron donating surface bearing palladium-containing metal particles. The stated modification targets include antimicrobial and biocompatibility-related endpoints such as bacterial adhesion and growth, protein adsorption, hydrophobicity, complement activation, inflammation, and thrombogenicity.

The document states broad applicability to medical and blood-contact devices, including contact lenses, pacemakers and electrodes, stents, dental implants, dialysis equipment, surgical instruments, catheters, wound dressings, and other blood-contact devices. Supporting examples describe tunable hydrophobicity, protein adsorption measurements using fibrinogen, reduced bacterial growth across multiple species, and immune response readouts including complement activation, platelet adhesion, and inflammatory cytokines.

Claims Coverage

The partial content includes one independent claim. It is supported by dependent claims that refine the electron donating surface material, the co-metal composition, quantitative constraints on metal particle amount and average particle size, and the categories of implant or device types.

Across the independent claim and dependent refinements, the coverage centers on surgical implantation of an implant having an electron donating surface bearing palladium-containing metal particles with specified co-metal selections and metal-particle loading, with further limitations on silver, gold, particle size and amount ranges, and enumerated implant or device categories.

Stated Advantages

Documented Applications