Gasket

Inventors

Spuhler, Philipp S. • Facer, Geoffrey R. • Li, Sixing • Cesar, Christopher G.

Assignees

Cellular Research Inc

Abstract

Disclosed herein are methods, devices, and systems for fluidic handling. In some embodiments, a gasket for providing a fluidic interface with a flowcell includes an inner cavity extending distally from a proximal end of the gasket, the inner cavity being defined by a plurality of inner surfaces sections, an inlet port positioned at a distal end of the inner cavity, an outlet port positioned at a distal end of the gasket, and a cannula extending between the inlet port and the outlet port; wherein at least some of the plurality of inner surface sections are tapered towards the distal end of the gasket to direct a pipette tip received within the gasket towards the inlet port of the gasket.

Core Innovation

The invention relates to a gasket for providing a fluidic interface with a flowcell. The gasket includes a proximal end and a distal end configured to be received within the flowcell, and an inner cavity extends distally through at least a portion of a first body section and is defined by a plurality of inner surface sections.

An inlet port is positioned at a distal end of the inner cavity and at a proximal end of a second body section. An outlet port is positioned at a distal end of the gasket, and a cannula extends between the inlet port and the outlet port and through at least a portion of a second body section and a third body section.

At least some inner surface sections are tapered toward the distal end of the gasket to direct a pipette tip received within the gasket toward the inlet port. The inner cavity can accommodate different pipette-tip sizes via inner-surface sections having different diameters, and the inner cavity geometry can include optional vents and recessed intermittent surface portions.

Claims Coverage

The document includes one independent claim. The claim coverage is focused on a gasket with an inner cavity defined by multiple inner surface sections, an inlet and outlet port connected by a cannula, and tapered inner surfaces configured to direct a received pipette tip toward the inlet port.

Across the independent claim, the core coverage is the combination of an inner cavity defined by a plurality of inner surface sections and tapered inner surfaces that direct a received pipette tip toward the inlet port, together with inlet and outlet ports connected by a cannula through the gasket body sections.

Stated Advantages

Documented Applications

No documented applications found