Apparatus and method for promoting fluid uptake into an implant
Inventors
Roorda, Wouter E. • Fischer, William G. M. • FISCHER, Kathleen • Mendelsohn, Adam D. • Monkowski, Adam
Assignees
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Publication Number
US-10525248-B2
Publication Date
2020-01-07
Expiration Date
Abstract
The invention pertains to apparatuses, means and methods to promote uptake of fluids into a reservoir of an implantable drug delivery system though a porous membrane. Embodiments of the invention promote fluid uptake by creating a pressure differential between the reservoir of the drug delivery device and the environment of the device after implantation, for instance a subcutaneous pocket.
Core Innovation
The invention relates to apparatuses for promoting fluid uptake into an implantable drug delivery device. The apparatus includes a housing and a tubular outer member slidably disposed within the housing, where the implantable drug delivery device is at least partially slidably disposed within the tubular outer member. The apparatus further includes an obturator that is at least partially slidably disposed within the tubular outer member and located proximal to the implantable drug delivery device.
A pressure reducer is configured to reduce the pressure inside a reservoir of the implantable drug delivery device containing a porous membrane, and to promote uptake of fluids into the reservoir. The porous membrane provides a pathway for mass transport through fluid flow between the reservoir and an environment of the implantable drug delivery device. The porous membrane is in fluid contact with the pressure reducer.
Embodiments described in the specification use pressure reduction to drive hydration or fluid uptake through a porous membrane, including nanoporous and nanotube membrane examples such as a titania nanotube membrane. The document describes accessory unit concepts and corresponding reservoir hydration contexts including a subcutaneous implantation environment.
Claims Coverage
The independent claims require an apparatus for promoting fluid uptake into an implantable drug delivery device, with three inventive features across the claims. The claims combine relative sliding structure with a pressure reducer that reduces pressure in a reservoir containing a membrane, and the membrane is in fluid contact with the pressure reducer.
Pressure-reducing apparatus with housing, tubular outer member, obturator, and reservoir porous membrane contact
An apparatus for promoting fluid uptake into an implantable drug delivery device comprising a housing; a tubular outer member at least partially slidably disposed within the housing; an implantable drug delivery device at least partially slidably disposed within the tubular outer member; an obturator at least partially slidably disposed within the tubular outer member and located proximal to the implantable drug delivery device; and a pressure reducer configured to reduce the pressure inside a reservoir of the implantable drug delivery device containing a porous membrane and to promote uptake of fluids into the reservoir, wherein the porous membrane provides a pathway for mass transport through fluid flow between the reservoir and an environment of the implantable drug delivery device, and wherein the porous membrane is in fluid contact with the pressure reducer.
Pressure-reducing apparatus with distal/proximal housing and attached tubular outer member
An apparatus for promoting fluid uptake into an implantable drug delivery device comprising a housing with a distal end and a proximal end; a tubular outer member with a distal end and a proximal end attached to the housing towards the distal end and having an affixed slider to slide the tubular outer member with respect to the housing; an implantable drug delivery device at least partially slidably disposed within the tubular outer member; a slideable obturator at least partially disposed within the tubular outer member and located proximal to the implantable drug delivery device; and a pressure reducer configured to reduce the pressure inside a reservoir of the implantable drug delivery device containing a membrane and to promote uptake of fluids into the reservoir.
Pressure-reducing apparatus using connector to a pressure reducer
An apparatus for promoting fluid uptake into an implantable drug delivery device comprising a housing with a distal end and a proximal end; a tubular outer member with a distal end and a proximal end attached to the housing towards the distal end and having an affixed slider to move the tubular outer member with respect to the housing; an implantable drug delivery device at least partially slidably disposed within the tubular outer member; a slideable obturator at least partially disposed within the tubular outer member and located proximal to the implantable drug delivery device; and a connector for connecting to a pressure reducer, wherein the pressure reducer is configured to reduce the pressure inside a reservoir of the implantable drug delivery device containing a membrane and to promote uptake of fluids into the reservoir.
The claims center on reducing pressure in a reservoir of an implantable drug delivery device having a porous membrane that provides a mass-transport pathway between the reservoir and the environment, with the porous membrane in fluid contact with the pressure reducer. They further define relative sliding structural elements and, in two claims, specify direct or connector-based pressure reducer implementation.
Stated Advantages
Promotes uptake of fluids into the reservoir of an implantable drug delivery device.
Enables mass transport through fluid flow between the reservoir and an environment of the implantable drug delivery device via the porous membrane in fluid contact with the pressure reducer.
Provides rapid or accelerated hydration/fluid uptake into an implantable drug delivery device reservoir in subcutaneous implantation contexts.
Documented Applications
Hydration/fluid uptake in a subcutaneous implantation context by exposing a reservoir through a porous membrane under reduced pressure.
Therapeutic protein and peptide delivery in which exenatide release is enabled after vacuum pretreatment.
Accessory hydration unit use cases for promoting hydration of an implantable drug delivery device reservoir.
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