Nutritional compositions containing an elevated level of inositol and uses thereof
Inventors
Kuang, Chenzhong • Xiao, Yan • Rudolph, Colin • Hondmann, Dirk
Assignees
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Publication Number
US-10525016-B2
Publication Date
2020-01-07
Expiration Date
Abstract
A method for enhancing neurological health and development in a subject involving administering to the subject a nutritional composition including no greater than about 7 g/100 kcal of a fat or lipid source; no greater than about 7 g/100 kcal of a protein or protein equivalent source; at least about 5 g/100 kcal of a carbohydrate; and at least about 9 mg/100 kcal of inositol, wherein the ratio of exogenous inositol to inherent inositol is at least 50:50.
Core Innovation
The invention relates to nutritional compositions that include inositol comprising exogenous inositol and inherent inositol. The compositions are characterized by specified macronutrient ranges and a specified amount of inositol per 100 kcal, together with an exogenous to inherent inositol ratio within the inositol fraction.
The invention addresses providing neurological benefits in a pediatric subject, including enhanced myelination and improved synaptic development. The described mechanisms include effects on oligodendroglial cells, including oligodendrocyte precursor cells, such as enhanced survival, proliferation, and differentiation, and increased myelin deposition.
The nutritional compositions may include optional co-nutrients, including long-chain polyunsaturated fatty acids such as docosahexaenoic acid and arachidonic acid, enriched milk fat fractions such as milk fat globules, and prebiotics such as polydextrose and galactooligosaccharides. Additional optional components described include lactoferrin, β-glucan, and other neurogenesis-associated lipids and phytochemicals.
Claims Coverage
The disclosed claim set includes one independent claim and multiple dependent claims that refine the independent claim by adding or constraining additional nutritional components. The core inventive features are directed to administering a nutritional composition with defined macronutrient ranges, a defined inositol amount consisting of exogenous and inherent fractions, and a defined exogenous-to-inherent inositol ratio to enhance myelin deposition in a pediatric subject.
Defined macronutrient and inositol ranges for pediatric myelin deposition
Administering to a pediatric subject a nutritional composition comprising about 2 g/100 kcal to about 7 g/100 kcal of a fat or lipid, about 1 g/100 kcal to no greater than about 7 g/100 kcal of a protein or protein equivalent, about 5 g/100 kcal to about 25 g/100 kcal of a carbohydrate, and about 12 mg/100 kcal to about 40 mg/100 kcal of inositol, wherein the inositol comprises exogenous inositol and inherent inositol.
Exogenous-to-inherent inositol ratio at least 75:25
The ratio of the exogenous inositol to the inherent inositol is at least 75:25.
Enhancing myelin deposition in neurons of a pediatric subject
Administration of the nutritional composition to the pediatric subject enhances myelin deposition in the neurons of the pediatric subject.
Long-chain polyunsaturated fatty acids including DHA or ARA
At least one long-chain polyunsaturated fatty acid includes docosahexaenoic acid or arachidonic acid.
Long-chain polyunsaturated fatty acid concentration range
The at least one long chain polyunsaturated fatty acid is present at a level from about 5 mg/100 kcal to about 75 mg/100 kcal.
Lactoferrin at about 10 mg/100 kcal to about 200 mg/100 kcal
Including lactoferrin at a specified concentration range of about 10 mg per 100 kcal to about 200 mg per 100 kcal.
Prebiotic composition of polydextrose and galactooligosaccharides with at least 20% w/w
Including a prebiotic composition made of polydextrose and galactooligosaccharides, where the prebiotic component is at least 20% w/w of those ingredients (including mixtures).
Infant formula or growing up milk product form
The nutritional composition is an infant formula or a growing up milk.
The claims focus on a method for enhancing myelin deposition in neurons of a pediatric subject by administering a nutritional composition with specified macronutrient ranges and an inositol amount comprising exogenous and inherent fractions, with an exogenous-to-inherent ratio of at least 75:25. Dependent claims further narrow the composition by specifying particular LCPUFAs, adding lactoferrin within a defined range, requiring a polydextrose/galactooligosaccharide prebiotic component at a minimum weight fraction, and restricting the product form to infant formula or growing up milk.
Stated Advantages
Enhances myelin deposition in the neurons of the pediatric subject.
Supports enhanced myelination through effects on oligodendrocyte precursor cells, including survival, proliferation, differentiation, and increased myelin deposition.
Enhances synaptic development, including increased synaptic marker density in neuron/synapse models.
Documented Applications
A method for enhancing myelin deposition in neurons of a pediatric subject by administering the specified nutritional composition.
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