Nutritional and medicinal oral composition for veterinary use
Inventors
BRUNEL, Nicolas • MARTINS, Fanny • GOISNARD, Patricia
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-10493032-B2
Publication Date
2019-12-03
Expiration Date
Abstract
The invention relates to a nutritional and medicinal oral composition for veterinary use, including a core of complete feed extrudate coated with at least one layer of fat. The layer of fat includes at least one medicinal agent which includes: (i) at least one preconditioned active principle in the form of a solution or a suspension of said active principle in an oily liquid, or (ii) at least one preconditioned active principle in the form of waxy granules.
Core Innovation
The invention relates to a nutritional and medicinal oral composition for veterinary use where a complete feed extrudate core is coated with at least one layer of fat. The fat layer comprises at least one medicinal agent, and the medicinal agent comprises at least one preconditioned active principle provided as non-encapsulated microparticles devoid of a protective outer layer.
The at least one preconditioned active principle is presented either as a solution or a suspension in an oily liquid or as waxy granules. The document positions the cold incorporation of an active principle without heat liquefaction and the use of preconditioned, non-microencapsulated microparticles as an approach to achieve taste masking/compliance, dose accuracy, and medicinal agent stability.
The described medicinal focus includes benazepril and benazepril salts, associated with ACE inhibition for renal insufficiency. Storage stability is evaluated by HPLC, and exposure and pharmacodynamic behavior are modeled and compared using PK/PD modeling against the commercial tablet Fortekor®.
Claims Coverage
The document includes one independent claim that defines a veterinary nutritional and medicinal oral composition with a complete feed extrudate core coated by at least one layer of fat, where the medicinal agent is provided as preconditioned, non-encapsulated microparticles without a protective outer layer and is formulated either as an oily-liquid solution/suspension or as waxy granules.
Fat-coated complete feed extrudate core for veterinary oral composition
A nutritional and medicinal oral composition for veterinary use comprising a core of complete feed extrudate coated with at least one layer of fat.
Medicinal agent as preconditioned active principle in non-encapsulated microparticles
The fat layer comprising at least one medicinal agent, said medicinal agent comprising at least one preconditioned active principle in the form of non-encapsulated microparticles devoid of a protective outer layer.
Oily liquid suspension or waxy granules presentation of the active principle
The at least one preconditioned active principle being in the form of a solution or a suspension of said active principle in an oily liquid, or waxy granules.
Across the independent claim, the inventive coverage centers on a veterinary oral composition where complete feed extrudate cores are fat-coated, and the medicinal agent is delivered as preconditioned, non-encapsulated microparticles without a protective outer layer, formulated either as an oily-liquid solution/suspension or as waxy granules.
Stated Advantages
Supports taste masking/compliance.
Supports dose accuracy.
Improves stability of the medicinal agent.
Provides prolonged exposure and ACE inhibition versus the comparison benazepril feed (Inv) benchmark.
Documented Applications
Veterinary treatment context for renal insufficiency (chronic disease) using benazepril-related ACE inhibition, with comparison to the commercial tablet Fortekor® and reported palatability/compliance in cats.
Interested in licensing this patent?