Spatially selective interventional neuroparticle with magnetoelectric material
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Publication Number
US-10485605-B2
Publication Date
2019-11-26
Expiration Date
Abstract
An apparatus and method stimulate or sense neurons or groups of neurons in a subject, e.g., a human or animal brain, with positional dependence. This utility is provided in part by utilizing individually-addressable Radio-Frequency IDentification (RFID) coils so that locations of those coils in the brain would be monitored and known.
Core Innovation
The invention describes an apparatus and a method for spatially selective stimulation or sensing in a living body using at least one radio particle introduced internal to the living body. A power source and at least one radio frequency antenna are located external to the living body and coupled together, and the external antenna provides selective emanation used to control the internal particle. The internal particle’s frequency identification device includes magnetoelectric material and is situated in or near one or more neurons within the living body.
The invention solves the problem of selectively stimulating or sensing at least one characteristic of neurons in a living body with positional dependence. It uses the externally located radio-frequency antenna to selectively stimulate or sense neuronal characteristics in response to a selective emanation, thereby enabling neuron-group level selectivity based on the internally-located particle’s position in or near the neurons. The selective emanation is used to control components included in the internally-located particle.
In one implementation, the RFID can be configured to support individually-addressable coils so that locations of the coils in a living body can be monitored. The RFID device can also be configured to receive data and/or instructions through radio frequency signals transmitted by at least one externally located radio frequency transmitter. Magnetoelectric material is further characterized in the RFID as a magneto-electric composite material exhibiting both magnetic and electric properties.
Claims Coverage
The independent claim set includes 2 independent claims (apparatus and method). Across these independent claims, the core inventive concept is controlling an internally introduced RFID-containing radio particle with magnetoelectric material using a selectively emanating externally located radio-frequency antenna to selectively stimulate or sense neuronal characteristics in or near neurons.
External radio-frequency power and antenna controlling an internal RFID particle in neurons
An apparatus where a power source and at least one radio frequency antenna located external to a living body are coupled together, and at least one radio particle including an RFID is introduced internal to the living body, wherein the internal RFID is situated in or near one or more neurons.
Magnetoelectric material in the internal RFID for selective neuronal stimulation or sensing
The apparatus where the at least one particle’s RFID includes magnetoelectric material and the internally-located particle includes components controlled using the externally-located radio-frequency antenna to selectively stimulate or sense at least one characteristic of the one or more neurons in response to a selective emanation from the externally-located radio frequency antenna.
External radio-frequency positioning and controlling method for internal magnetoelectric RFID particles
A method positioning a power source and at least one radio frequency antenna coupled together external to a living body; introducing at least one radio particle including an RFID internal to the living body, wherein the RFID includes magnetoelectric material; positioning the RFID situated in or near one or more neurons; and controlling the internally-located particle using the externally radio-frequency antenna to selectively stimulate or sense at least one characteristic of the one or more neurons in response to a selective emanation.
Both independent claims require an external radio-frequency antenna and power source, an internal RFID-containing radio particle situated in or near neurons, and control of the internal particle by selective emanation to selectively stimulate or sense neuronal characteristics, with the RFID including magnetoelectric material.
Stated Advantages
Provides spatially selective stimulation or sensing of at least one characteristic of neurons in response to a selective emanation.
Enables selectivity with positional dependence by positioning the RFID particle in or near one or more neurons.
Documented Applications
Spatially selective neuronal stimulation or sensing in a living body using individually-addressable RFID coils.
Monitoring location of RFID coil(s) in a living body when individually-addressable coils are included.
Receiving data and/or instructions through radio frequency signals via the RFID device.
Imaging/localization via magnetic resonance, magnetic particle, or electrical imaging is discussed in the document.
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