Composition having hydrolyzed collagen and manuka honey
Inventors
Assignees
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Publication Number
US-10471106-B2
Publication Date
2019-11-12
Expiration Date
Abstract
The composition having hydrolyzed collagen and Manuka honey includes hydrolyzed collagen in an amount ranging from between 5% to 95% by weight and Manuka honey in an amount ranging from between 5% to not greater than 50% by weight in water. The Manuka honey can have a methylglyoxal concentration greater than 100 mg/kg, and preferably greater than 550 mg/kg.
Core Innovation
The disclosed invention relates to a wound-healing composition that includes hydrolyzed collagen and Manuka honey in water, where the hydrolyzed collagen ranges from 5–95 wt% and the Manuka honey ranges from 5–50 wt%. The Manuka honey is characterized by a methylglyoxal concentration greater than 100 mg/kg, preferably greater than 550 mg/kg.
The disclosed rationale is that methylglyoxal provides antimicrobial activity, while hydrolyzed collagen and honey are proposed to crosslink via collagen amino groups with methylglyoxal. This is described as supporting extracellular matrix (ECM)-like wound bed formation, including conversion of sodium hyaluronate, and enabling controlled gel or film formation.
The invention further states that the composition and resulting wound outcomes can improve scar-free healing and wound healing performance. It also describes suitable topical and other dosage forms, and explains that antimicrobial benefits are temperature sensitive in relation to the preparation.
Claims Coverage
The document includes one independent claim and multiple dependent claims. The inventive features focus on making a homogenized gel composition by controlled heating of water, hydrolyzed collagen, and Manuka honey, together with defined ranges for collagen content, Manuka honey content, and Manuka honey and collagen quality parameters.
Heating water and forming a viscous gel with hydrolyzed collagen
The method includes heating water to between 135°F and 145°F, mixing the heated water with hydrolyzed collagen powder to form a viscous gel, and maintaining the viscous gel at a constant temperature.
Heating Manuka honey and adding it to the viscous gel to form a homogenized gel composition
The method includes heating the Manuka honey to between 115°F and 130°F and adding the heated Manuka honey to the viscous gel to form the homogenized gel composition.
Compositional ranges for hydrolyzed collagen and Manuka honey
The hydrolyzed collagen is present at between 5% and 95% by weight of the composition, and the Manuka honey is present at between 5% and 50% by weight of the composition.
Manuka honey methylglyoxal level constraints
The Manuka honey has a methylglyoxal concentration of at least 100 mg/kg, including a refinement where the Manuka honey has a methylglyoxal concentration of at least 550 mg/kg.
Hydrolyzed collagen molecular weight range
The hydrolyzed collagen has a molecular weight between 500 and 10,000 Daltons.
Overall, the claim set centers on producing a homogenized gel composition by separately heating water/hydrolyzed collagen and Manuka honey within specified temperature ranges, combining them under controlled temperature maintenance, and requiring defined composition percentages and quality constraints for Manuka honey methylglyoxal and hydrolyzed collagen molecular weight.
Stated Advantages
Antimicrobial activity attributed to methylglyoxal.
Supports extracellular matrix (ECM)-like wound bed formation, including conversion of sodium hyaluronate.
Enables controlled gel or film formation.
Improves scar-free healing and wound outcomes.
Documented Applications
Wound healing using a composition in topical and other dosage forms (e.g., gels, sprays, pastes, foams, films, dressings, patches, and injectable or oral liquid/tablet/capsule forms).
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