Injection devices

Inventors

Hoffmann, RolfHohlrieder, Martin

Assignees

Replicel Life Sciences Inc

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Publication Number

US-10463806-B2

Patent

Publication Date

2019-11-05

Expiration Date


Abstract

The invention relates to an injection device. Exemplary embodiments of the invention comprise an application element, an injection needle, an injection needle housing, a drive system for the injection movement, and a retraction system. In exemplary embodiments, a substance is injected during the retraction movement of the injection needle.

Core Innovation

The invention relates to an injection device for introducing a substance into the body of a subject. The injection device comprises an application element, at least one injection needle, and an injection needle housing, together with a drive system for the injection movement and a retraction system for a retraction movement.

A key concept is that the substance is injected during the retraction movement of the injection needle. The drive system comprises a micro linear pusher, and the injection is conducted with an injection system comprising a motor, a lead screw and a screw nut. The described motion concept enables injection during retraction along a defined retraction movement.

The described operation is directed to gentle, slow retraction to reduce pressure and/or shear on sensitive cells, inhibit reflux, and reduce risk of blood-vessel injury. The device supports introducing substances such as cell suspensions into tissue layers with distributed delivery over a defined retraction path, where the retraction path can include adjustable depth and angle.

Claims Coverage

The independent claim contains two inventive features: an injection device with a micro linear pusher drive system and retraction system, and injection of the substance during needle retraction using a motor, lead screw and screw nut. Dependent claims further refine the mechanical coupling and timing relationships and specify an application site.

Micro linear pusher drive and retraction injection timing

An injection device comprising an application element, at least one injection needle, an injection needle housing, a drive system for the injection movement wherein the drive system comprises a micro linear pusher, and a retraction system for a retraction movement, wherein the substance is injected during the retraction movement of the injection needle.

Motor lead screw and screw nut injection system

The injection of the substance is conducted with an injection system comprising a motor, a lead screw and a screw nut.

Overall, the claim coverage centers on delivering substance during needle retraction using a retraction system and a micro linear pusher drive, and on performing that injection with a motor–lead screw–screw nut injection system.

Stated Advantages

Gentle, slow retraction to reduce pressure and/or shear on sensitive cells.

Inhibiting reflux.

Reducing risk of blood-vessel injury.

Enabling distributed delivery over a defined retraction path.

Providing adjustable depth and injection angle.

Documented Applications

Introducing cell suspensions into tissue layers using distributed injection over a defined retraction path.

Scalp/hair loss treatment, including application to dermal sheath cup cells (DSC).

Injection into dermal layers and tissue regions including muscle/tendon as described in the examples.

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