Systems and methods for monitoring medication effectiveness
Inventors
Kohli, Sandeep S. • Widman, David • Kaul, Robert • Ross-Howe, Sara
Assignees
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Publication Number
US-10463299-B1
Publication Date
2019-11-05
Expiration Date
Abstract
System for determining the effectiveness of various prescribed medications. Here a variety of different types of patient pulse wave measurements (e.g. blood pressure, pulse oximeter, ECG) and other physiological measurements are obtained. This actual data is compared to calculated measurements that would be expected based on the various patient baseline measurements in the absence of medication, schedule of medications, and impact of medications the various patient baseline measurements. If the actual data meets expectations, then the medication is likely acting as anticipated. Depending on which types of data do not meet expectations, problems with one or more previously described medications may be reported. Other types of patient physiological readings, such as temperature, motion, lung function, brain wave function (EEG) and the like may also be obtained, and these additional types of readings can be used to extend the range of different types of drugs/medications that the system can successfully monitor.
Core Innovation
The invention determines effectiveness of at least one specific medication from a medication regimen comprising a plurality of medications by comparing patient pulse-wave-related measurements with expected patient pulse wave measurements. The method uses patient operable instrumentation comprising a plurality of different types of time varying pulse wave measurements including electrode-based time varying electrocardiograph (ECG) readings, time varying blood oxygen saturation levels, and time varying blood pressure measurements. The instrumentation is a unitized, common processor controlled system and obtains the different types of actual patient pulse wave measurements at a known time.
The method obtains a plurality of individual medication impact parameters, each providing information on how an individual known specific medication alters a specific type of pulse wave measurements. The method also obtains a plurality of patient reference information, each providing information on a specific type of patient baseline pulse wave measurement in an absence of patient medication. Using patient medication schedule information for the patient, the processor calculates expected patient pulse wave measurements based on the known time, the patient reference information, and the medication impact parameters.
The invention then determines which of the different types of actual patient pulse wave measurements are inconsistent with the expected patient pulse wave measurements, producing specific medications with inconsistent findings. Based on the inconsistent findings, the processor determines effectiveness and medication adherence to the regimen, and establishes or refines the effectiveness based on the medication adherence. The effectiveness comprises an impact of the specific medication on the patient's actual patient pulse wave measurements as compared to the calculated expected patient pulse wave measurements for the medication regimen.
Claims Coverage
Two independent claims are covered: a method claim and a device claim. Each independent claim includes five inventive features centered on multi-type time varying pulse-wave measurement acquisition, expected-measurement calculation from a patient medication schedule with medication impact parameters and patient reference data, and inconsistency-based determination of medication effectiveness and medication adherence.
Unitized patient operable pulse-wave monitoring for ECG, oxygen saturation, and blood pressure
A method/device obtains a plurality of different types of actual patient pulse wave measurements comprising electrode-based time varying electrocardiograph (ECG) readings, time varying blood oxygen saturation levels, and time varying blood pressure measurements; with patient operable instrumentation that is a unitized, common processor controlled system having at least one processor and memory.
Medication impact parameters and patient reference information
The method/device obtains and stores a plurality of individual medication impact parameters, each providing information on how an individual known specific medication alters a specific type of pulse wave measurements, and obtains and stores a plurality of patient reference information, each providing information on a specific type of patient baseline pulse wave measurement in an absence of patient medication.
Expected patient pulse wave measurements from medication schedule at known time
The method/device obtains patient medication schedule information associated with a plurality of medications and medication dosing schedules for the patient, and calculates expected patient pulse wave measurements based on the patient medication schedule information, the known time, the patient reference information, and the medication impact parameters.
Inconsistent findings drive medication effectiveness and medication adherence determination
The method/device determines which of the plurality of different types of actual patient pulse wave measurements are inconsistent with the expected patient pulse wave measurements, stores at least the specific medications with inconsistent findings, and determines effectiveness and a medication adherence to the regimen based on the inconsistent findings.
Effectiveness defined as impact versus calculated expected measurements
The method/device defines effectiveness as an impact of the at least one specific medication on a patient's actual patient pulse wave measurements as compared to calculated expected patient pulse wave measurements for the medication regimen.
Overall, the claims cover a method and a device that use a unitized multi-modality pulse-wave measurement system, compute expected measurements from medication schedule, patient baseline reference, and per-medication impact parameters, and determine medication effectiveness through inconsistency detection, including medication adherence.
Stated Advantages
Determines effectiveness of at least one specific medication from a medication regimen by comparing actual patient pulse wave measurements to calculated expected patient pulse wave measurements.
Determines medication adherence to the regimen based on inconsistent findings.
Establishes or refines effectiveness based on the medication adherence.
Stores specific medications with inconsistent findings in memory.
Documented Applications
Not explicitly described in patent.
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