Compositions and associated methods for radioisotope-binding microparticles
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Publication Number
US-10434200-B2
Publication Date
2019-10-08
Expiration Date
Abstract
The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.
Core Innovation
The invention relates to polymeric injectable/implantable microparticles (microspheres) for detectable radionuclide therapy and vascular embolization, where the microspheres are associated with a radioisotope through chelation. The core concept is to use a chelating agent incorporated into the polymeric microparticles so that the chelating agent is configured to chelate a radioisotope.
The polymeric microspheres include a polymerized monomer and a chelating agent that comprises a polymerizable group. The chelating agent comprises a compound of Formula I, where n is between 1 and 18 inclusive, Xa and Xb may independently be O, S or N, and R may be alkyl or H, and the polymerizable group is polymerized with the monomer and incorporated into a polymer of the polymeric microsphere.
The documented compositions include microparticles that contain between about 1% and about 20% by weight of chelating agent, and the microspheres have a diameter ranging from about 1 micrometer to about 2000 micrometers suitable for embolization. The chelating agent polymerization enables radioisotope chelation.
Claims Coverage
Two independent claims are present. They cover fabrication of embolic polymeric microspheres by polymerizing a monomer with a polymerizable Formula I chelating agent configured to chelate a radioisotope, with defined chelating-agent loading and microsphere diameter.
Polymerizable formula I chelating agent incorporated into an embolic polymeric microsphere
Fabricating a polymeric microsphere comprising a polymerized monomer and a chelating agent, wherein the chelating agent comprises a compound of Formula I, and the polymerizable group of the chelating agent is polymerized with the monomer and incorporated into the microsphere polymer.
Chelating agent configured to chelate a radioisotope
The chelating agent is configured to chelate a radioisotope such that the microsphere is suitable for embolization.
Defined chelating-agent loading and microsphere diameter
The microsphere comprises between about 1% and about 20% by weight of chelating agent and has a diameter ranging from about 1 micrometer to about 2000 micrometers.
Acrylamide monomer embodiment
The monomer comprises an acrylamide, and the acrylamide-containing monomer is polymerized with a chelating agent comprising a polymerizable group and Formula I.
The central coverage is the fabrication of embolic polymeric microspheres that incorporate a polymerizable Formula I chelating agent into the polymer matrix so that the chelating agent is configured to chelate a radioisotope, with defined chelating-agent loading and microsphere diameter suitable for embolization.
Stated Advantages
Microspheres suitable for embolization.
Enables detectable radionuclide therapy and embolization by associating a microsphere with a radioisotope through chelation.
Overcomes limitations of conventional radiopaque dyes/agents by using radioisotope association via chelation.
Documented Applications
Detectable radionuclide therapy using polymeric microspheres associated with a radioisotope via chelation.
Vascular embolization using embolic polymeric microspheres suitable for embolization.
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