Method and system for dose rate regulation in drug infusion treatment
Inventors
Assignees
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Publication Number
US-10426888-B2
Publication Date
2019-10-01
Expiration Date
Abstract
A system for drug delivery by infusion is disclosed where the concentration of the drug solution withdrawn from a drug container (1, 2) to be delivered to the patient (8) according to a predetermined dose rate protocol for the drug is repeatedly analyzed during the infusion, and the concentration data obtained are used to continuously control the infusion rate to at least substantially maintain the predetermined dose rate. A method for drug delivery by infusion is also disclosed.
Core Innovation
The disclosed invention relates to a system for administering a drug solution by infusion in which a detection chamber is provided in a fluid conduit between the drug container and patient connection means. The system includes analytical detection means for non-invasive determination in the detection chamber of the identity and concentration of the drug in fluid withdrawn from the drug container into the fluid conduit, while adjustment means set an infusion rate corresponding to a predetermined dose rate based on label concentration.
The system prevents infusion if the label drug is not identified. When the drug identity is identified but the drug concentration determined in the detection chamber deviates from the label concentration, a control unit is arranged to calculate and set the adjustment means to an adjusted infusion rate to at least substantially maintain the predetermined dose rate.
The disclosed approach further comprises a blood analysis system to measure the biological response to the actual dose rate, and information obtained from that blood analysis system is used as a variable in the dose rate setting. The disclosed approach therefore integrates non-invasive drug identity and concentration determination with dose-rate adjustment and additional feedback from biological response for the dose rate protocol.
Claims Coverage
Two independent claims are identified. They share the inventive core of non-invasive drug identity and concentration determination in a detection chamber, infusion prevention when identity is not confirmed, and recalculation of an adjusted infusion rate to maintain a predetermined dose rate; both claims also include a blood analysis system as a variable in dose rate setting.
Infusion system with detection chamber for non-invasive identity and concentration determination
A system for administering a drug solution by infusion comprising a drug container with a label drug solution and label concentration, a drug delivery set with a fluid conduit, a detection chamber in the fluid conduit between the drug container and patient connection means, analytical detection means for non-invasive determination in the detection chamber of the identity and concentration of the drug in fluid withdrawn from the drug container into the fluid conduit, and adjustment means for setting an infusion rate corresponding to a predetermined dose rate based on the label concentration.
Infusion prevention based on identity and infusion-rate recalculation to maintain predetermined dose rate
Means for preventing infusion of drug solution from the drug container if the label drug is not identified, and a control unit arranged to control the adjustment means and configured to calculate and set the adjustment means to an adjusted infusion rate to maintain the predetermined dose rate when the drug concentration determined in the detection chamber deviates from the label concentration.
Blood analysis system as variable in dose rate setting
The system further comprises a blood analysis system to measure the biological response to the actual dose rate, wherein information obtained therefrom is used as a variable in the dose rate setting.
Method with non-invasive identity and concentration determination and conditional infusion
A method of administering a drug solution by infusion comprising providing a drug container with a label drug solution containing a label concentration, coupling the drug container to a drug delivery set for administration via a fluid path containing a detection chamber, based on the label concentration setting an infusion rate corresponding to a predetermined dose rate, withdrawing drug solution through the detection chamber and non-invasively determining identity and concentration of the drug in the detection chamber, permitting infusion if the label drug is identified and the determined concentration corresponds to the label concentration, preventing infusion if the label drug is not identified, and calculating and setting an adjusted infusion rate if identity is identified but the determined concentration does not correspond to the label concentration to at least substantially maintain the predetermined dose rate.
Using blood analysis information as variable in dose rate setting in the method
Using information from a blood analysis system as a variable in the dose rate setting, said blood analysis system measuring the biological response to the actual dose rate.
Across the independent claims, the inventive coverage centers on non-invasive determination of drug identity and concentration in a detection chamber during infusion, preventing infusion when identity is not confirmed, and calculating and setting an adjusted infusion rate to at least substantially maintain a predetermined dose rate when concentration deviates; the disclosed approach further integrates a blood analysis system measuring biological response as a variable in dose rate setting.
Stated Advantages
Prevents infusion of drug solution if the label drug is not identified.
Maintains a predetermined dose rate at least substantially when the determined drug concentration deviates from the label concentration.
Uses biological response measured by a blood analysis system as a variable in dose rate setting.
Documented Applications
Not explicitly described in patent.
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