Method for treatment of disease caused or aggravated by microorganisms or relieving symptoms thereof
Inventors
Ghannoum, Afif Mahmoud • Sokol, Brian Vincent
Assignees
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Publication Number
US-10426761-B2
Publication Date
2019-10-01
Expiration Date
Abstract
A method for treating a disease or for treating a symptom of a disease, or a combination of both, the disease being caused or aggravated by microorganisms includes: treating the disease, treating the symptom of the disease, or reducing the duration of the disease, or a combination of both by administering a barrier-forming composition in a therapeutically effective amount to a surface, the surface comprising a mammal mucosa, the mammal being infected with the disease or experiencing symptoms of the disease caused or aggravated by the microorganisms. The barrier-forming composition includes an antimicrobial. Upon administering the composition, the method includes forming a barrier coating on the surface that is active to kill or neutralize microorganisms encountered by the barrier coating. A composition with an agent active for relieving symptoms of a disease is also included.
Core Innovation
The invention relates to barrier-forming antimicrobial compositions and to methods for treating or preventing a disease by administering the composition to a surface comprising mammal mucosa. The composition forms a barrier coating on the mucosal surface that is active to kill or neutralize microorganisms encountered by the barrier coating.
The barrier-forming composition comprises an antimicrobial and is described as effective because the barrier coating traps and kills or neutralizes microorganisms. The antimicrobial activity includes binding to a cell membrane of the microorganisms, disrupting the cell membrane, and thereby causing cell death.
The composition is characterized by specific weight-percentage requirements for a carbohydrate gum (C), a humectant (H), and an antimicrobial agent (A), where about 0.0001%≤C<0.4%, about 0.07%≤H≤about 70%, and 0.0005%<A, with all percentages by weight of the total composition. The barrier-forming composition is also described with viscosity less than 500 cps and activity after administration as measured by reduced microbial burden over time.
Claims Coverage
Two independent claims are provided. Across these claims, the central inventive theme is administering a therapeutically effective barrier-forming composition to mammal mucosa infected with or experiencing a viral upper respiratory infection, where a barrier coating plus antimicrobial action kills or neutralizes encountered microorganisms to reduce infection duration, frequency, or symptom severity, under defined composition constraints for carbohydrate gum C, humectant H, and antimicrobial A.
Treating a viral upper respiratory infection via a barrier-forming composition on mammal mucosa
A method for treating a viral upper respiratory infection or treating a symptom thereof, or reducing duration, by administering a therapeutically effective barrier-forming composition to a surface comprising mammal mucosa so that the composition forms a barrier coating that is active to kill or neutralize microorganisms encountered by the barrier coating, wherein the composition reduces duration, frequency, or severity of cough, sore throat, and fever and meets about 0.0001%≤C<0.4%, about 0.07%≤H≤about 70%, and 0.0005%<A by weight, with C as a carbohydrate gum, H as a humectant, and A as the antimicrobial agent.
Cell membrane binding antimicrobial barrier composition that is safe and free of harmful side effects
A method for treating a viral upper respiratory infection or treating a symptom thereof, or reducing duration, by administering a therapeutically effective barrier-forming composition to a surface comprising mammal mucosa where the mammal is infected with the viral upper respiratory infection, the barrier-forming composition comprising an antimicrobial agent that binds to a cell membrane of the microorganisms and disrupts the cell membrane thereby causing cell death, effectively reducing duration, frequency, or severity of the viral upper respiratory infection or symptoms, the method being safe and free of harmful side effects, and the composition meeting about 0.0001%≤C<0.4%, about 0.07%≤H≤about 70%, and 0.0005%<A by weight, with C as a carbohydrate gum, H as a humectant, and A as the antimicrobial agent.
The independent claims are directed to forming an active barrier coating on mammal mucosa via a therapeutically effective barrier-forming composition with defined carbohydrate gum, humectant, and antimicrobial weight ranges, and to antimicrobial action that binds to and disrupts microorganism cell membranes to cause cell death, with the method described as safe and free of harmful side effects to reduce viral upper respiratory infection duration, frequency, or symptom severity.
Stated Advantages
Reduces duration, frequency, or severity of cough, sore throat, and fever.
Effectively reduces duration, frequency, or severity of the viral upper respiratory infection or one or more symptoms of the viral upper respiratory infection.
Method is safe and free of harmful side effects.
Documented Applications
Treating a viral upper respiratory infection.
Treating a symptom of a viral upper respiratory infection.
Reducing duration of a viral upper respiratory infection.
Reducing one or more symptoms including cough, sore throat, and fever.
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