Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy

Inventors

Westman, Jacob

Assignees

Curovir AB

Abstract

A compound of formula (I), or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection.

Core Innovation

The disclosure describes compounds of formula (I) and pharmaceutically acceptable salts thereof, defined by structural-variable constraints including W as CH2 or CH2–CH2, X as C, ring A as phenyl or a 5- or 6-membered heteroaryl ring, and m as an integer of from 0 to 3. The compounds further include multiple substituent options defined for R1 and the additional R groups, including halogen and heteroatom-containing groups.

When m is at least 2, two R1 attached to adjacent atoms of ring A may form, together with their attachment atoms, a 5- or 6-membered heterocyclic or carbocyclic ring. The document presents the compound of formula (I) in pharmaceutical compositions with pharmaceutically acceptable excipients and in multiple dosage forms, including topical lotion/cream, rectal suppository, and enema formulations.

The document states therapeutic use for viral infection and addresses diseases caused by RNA viral infection, in particular picornaviruses such as parechoviruses, cardioviruses, and enteroviruses including coxsackie and polio. It also links the disclosed compounds to PI4K IIIβ inhibition and includes product-use language indicating use in manufacturing a medicament and administration to humans and animals.

Claims Coverage

The claim set covers a formula (I) compound class defined by a variable linker W, defined core constraints, and specific R-group substitution options. Independent and dependent claims together define the scaffold variables, selected ring A and W limitations, constrained m values, selected substituted derivatives, pharmaceutical composition, and treatment of viral infection in a mammal.

Overall, the claims provide a structural definition for compounds of formula (I) or pharmaceutically acceptable salts centered on a substituted scaffold with variables W, ring A, and m and multiple R substituents. Dependent claims narrow the scaffold by specifying ring A, fixing W, constraining m, and selecting from explicitly listed substituted derivatives, with additional claims covering pharmaceutical composition formulation and a method for treating a viral infection in a mammal by administering the claimed compounds.

Stated Advantages

Documented Applications