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Publication Number
US-10406524-B2
Publication Date
2019-09-10
Expiration Date
Abstract
A reagent preparation assembly includes a body and a reaction chamber adjacent the body, the reaction chamber includes a reagent therein, such as a lyophilized reagent. An access port extends into the reaction chamber, and the access port is configured to receive an instrument. A seal extends across a portion of the reaction chamber and the access port. A reconstitution assembly is movably coupled with the body. The reconstitution assembly includes a plunger, a syringe and a piston. The plunger is movably coupled with the body. The syringe is selectively engaged with the plunger. The syringe includes a solution reservoir containing a solution, and movement of the syringe pierces the seal. The piston is selectively engaged with the plunger, and the piston is movably coupled within the syringe. Movement of the piston pushes the solution into the reaction chamber.
Core Innovation
The invention relates to a reagent preparation assembly that includes a reaction chamber containing an unreconstituted reagent, with the reaction chamber configured with an access port extending toward the reaction chamber to receive an instrument. The assembly further includes a body coupled with the reaction chamber and a syringe passage within the body extending toward the reaction chamber and a syringe port. The syringe passage is isolated from the reaction chamber with a syringe seal.
A reconstitution assembly is coupled with the body and includes a plunger movable between initial, piercing and solution moving positions. In the initial position, a syringe is suspended above the syringe seal and the reaction chamber, and the syringe includes a solution reservoir containing a solution. In the piercing position, the plunger is moved to drive the syringe through the syringe seal.
In the solution moving position, the plunger is moved relative to the piercing position so that the piston within the syringe pushes solution from the solution reservoir into the reaction chamber. The disclosed structures support controlled reconstitution and transfer through sealing and chamber geometry, including a reaction chamber arranged to localize the reconstituted reagent mixture beneath the access port for accurate withdrawal.
Claims Coverage
The partial content provides one independent claim, which sets out the overall reagent preparation assembly using a reaction chamber with an unreconstituted reagent, an access port for an instrument, and a plunger-driven syringe reconstitution sequence including an isolated syringe passage with a syringe seal.
Reagent chamber with access port and isolated syringe passage
A reaction chamber includes an unreconstituted reagent, an access port extending toward the reaction chamber is configured to receive an instrument, and a body is coupled with the reaction chamber. A syringe passage within the body extends toward the reaction chamber and a syringe port, and the syringe passage is isolated from the reaction chamber with a syringe seal.
Plunger-driven syringe through syringe seal into reaction chamber
A reconstitution assembly coupled with the body includes a plunger movable between initial, piercing and solution moving positions. In the initial position a syringe is suspended above the syringe seal and the reaction chamber, and the syringe includes a solution reservoir containing a solution; in the piercing position the plunger drives the syringe through the syringe seal; and in the solution moving position the plunger drives a piston within the syringe so that the piston pushes solution from the solution reservoir into the reaction chamber.
Across the single independent claim, the inventive coverage centers on combining a reaction chamber holding an unreconstituted reagent with an access port for receiving an instrument, while using a reconstitution assembly in which a plunger drives a syringe through a syringe seal and then drives a piston to push solution into the reaction chamber.
Stated Advantages
Controlled reconstitution and transfer through sealing and chamber geometry.
Localize the reconstituted reagent mixture beneath the access port for accurate withdrawal.
Documented Applications
No documented applications found
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