Devices for estimating regional metabolic rate of organs based on heat generation and for estimating regional blood flow(s) for the volume(s) of tissue perfused
Inventors
Pile-Spellman, John • Choi, Jae H.
Assignees
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Publication Number
US-10363364-B2
Publication Date
2019-07-30
Expiration Date
Abstract
The present application provides systems that include a controller, and an insertion device with at least one temperatures sensor thereon and a pump coupled to the controller. The insertion device provides temperature measurement(s) at/of a subject's organ to the controller and the controller varies an infusate flow rate to induce temperature changes in at least a portion of the subject's organ and stores the temperature measurements during perfusion induced temperature changes on a memory device. The controller may estimate at least one hemodynamic characteristic of at least a portion of the subject's organ based on the temperature measurements obtained during perfusion induced temperature changes.
Core Innovation
A controller-driven system estimates values for hemodynamic characteristics of at least a portion of a subject’s organ using a plurality of temperature measurements obtained during perfusion induced temperature changes. The system includes an insertion device having at least one temperature sensor functionally coupled to the controller, and a pump functionally coupled to the controller to vary an infusate flow rate to induce temperature changes. The controller varies the pump to induce temperature changes between a first temperature and a second temperature in a sequence that includes raising and lowering to at least one step temperature between the first and second temperatures, and maintaining the step temperature and at least one of the first and second temperatures for a given time.
The system stores the plurality of temperature measurements throughout wash-in and wash-out perfusion induced temperature changes, and uses time as a variable to estimate values for at least one hemodynamic characteristic based on the plurality of temperature measurements. The temperature cycling is described in terms of at least one of a wash-in and a wash-out cycle, with time-resolved measurements taken during wash-in, equilibrium, and wash-out.
The described estimation links temperature change information to tissue heat production and perfusion-related parameters, including at least one of regional metabolic rate of oxygen (CMRO2) and oxygen extraction fraction (OEF), and perfusion-related quantities such as tissue perfused volume, penumbra tissue perfused volume, and reperfusion hyperemia/severity indices. The system further references a penumbra sparing threshold temperature (PST) and discusses computational modeling using heat transfer/bio-heat concepts, including a two-compartment model comparing normal versus ischemic tissue, to produce example outputs during endovascular intervention and physiological monitoring.
Claims Coverage
The independent claim contains a system-level controller/perfusion/estimation architecture with temperature-sensor input, wash-in/wash-out pump-controlled temperature sequencing, storage of time-resolved measurements, and estimation of at least one hemodynamic characteristic using time as a variable (1 inventive feature group). Only one independent claim is provided in the supplied claim set.
Controller-driven temperature-sequenced perfusion with step temperatures and wash-in/wash-out control
A system with a controller and an insertion device providing a plurality of temperature measurements, and a pump controlled by the controller to vary an infusate flow rate to induce temperature changes in at least a portion of the organ in accordance with at least one of a wash-in and a wash-out cycle, where the controller varies the pump to induce temperature changes between a first temperature and a second temperature including at least one step temperature between them, and maintains the step temperature and at least one of the first and second temperatures for a given time.
Time-resolved temperature measurement storage and hemodynamic characteristic estimation
A memory device storing the plurality of temperature measurements taken throughout the at least one of wash-in and wash-out perfusion induced temperature changes, where the controller estimates values for at least one hemodynamic characteristic of at least a portion of the subject’s organ based on the plurality of temperature measurements and time as a variable.
Across the provided independent claim, the core inventive coverage is a controller-led system that performs wash-in/wash-out pump-driven, step-based temperature sequencing while recording temperature over time, and then estimates at least one hemodynamic characteristic from the stored time-resolved temperature measurements.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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