Oxygen supply for organ perfusion systems
Inventors
Kay, Stuart Brian William • Cuvelier, Sebastien Antoine Yves • Oakley, Jonathan Richard • Russell, Leslie James • Friend, Peter John • Coussios, Constantin C.
Assignees
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Publication Number
US-10362780-B2
Publication Date
2019-07-30
Expiration Date
Abstract
A perfusion system for the perfusion of an organ comprises a perfusion fluid circuit (16) for circulating perfusion fluid through the organ, oxygenation means (14) for adding oxygen into the perfusion fluid, and an oxygen supply arranged to supply oxygen to the oxygenation means. The oxygen supply comprises an oxygen concentrator.
Core Innovation
The disclosed invention relates to an extracorporeal perfusion system for the perfusion of an organ, comprising a perfusion fluid circuit for circulating perfusion fluid through the organ and an oxygenator for adding oxygen into the perfusion fluid. The oxygenator comprises a duct to carry the perfusion fluid, an oxygen chamber, and a permeable membrane between the duct and the oxygen chamber, and oxygen is supplied to the oxygen chamber while carbon dioxide is extracted so that the perfusion fluid is oxygenated and carbon dioxide passes out.
The system further comprises an oxygen supply arranged to supply oxygen to the oxygenator, wherein the oxygen supply comprises an oxygen concentrator. The oxygen concentrator includes an inlet arranged to receive gas in the form of air, a compressor arranged in the inlet, and a nitrogen extractor arranged to extract nitrogen from the gas thereby to increase the oxygen concentration of the gas. In addition to the oxygen supply, an air supply is arranged to supply air to the oxygenator, with an air control valve arranged to control the flow rate of air and an oxygen control valve arranged to control the flow rate of oxygen to the oxygen chamber.
A carbon dioxide sensor measures a carbon dioxide content of the perfusion fluid and an oxygen sensor measures an oxygen content of the perfusion fluid. A controller defines a first target range for said oxygen content, monitors the measured oxygen content, and controls the oxygen control valve and the compressor to maintain the oxygen content within the first target range. The controller also defines a second target range for said carbon dioxide content, monitors the measured carbon dioxide content, and controls the air control valve in response to the measured carbon dioxide content to maintain the carbon dioxide content within the second target range.
In a further configuration, warm perfusion fluid is used, together with a heater and a thermometer to measure the temperature of the perfusion fluid.
Claims Coverage
The document includes two independent claims that share the core architecture of an organ perfusion system with an oxygenator, an oxygen concentrator with nitrogen extraction, oxygen and carbon dioxide sensors, and closed-loop control to maintain first and second target ranges. Across the independent claims, the inventive feature set is centered on membrane oxygenation with separately controlled oxygen and air supply, sensor-driven range maintenance, and, in one independent claim, heating with temperature measurement.
Permeable membrane oxygenator with oxygen and air chamber supplies
An oxygenator for adding oxygen into the perfusion fluid, the oxygenator comprising a duct to carry the perfusion fluid, an oxygen chamber, and a permeable membrane between the duct and the oxygen chamber, wherein an oxygen supply supplies oxygen to the oxygenator and an air supply supplies air to the oxygenator.
Oxygen concentrator with nitrogen extraction for increased oxygen concentration
An oxygen supply arranged to supply oxygen to the oxygenator, wherein the oxygen supply comprises an oxygen concentrator, the oxygen concentrator comprising an inlet arranged to receive gas in the form of air, a compressor arranged in the inlet, and a nitrogen extractor arranged to extract nitrogen from the gas thereby to increase the oxygen concentration of the gas.
Closed-loop oxygen content maintenance using oxygen control valve and compressor
A controller arranged to define a first target range for said oxygen content, monitor the measured oxygen content and to control the oxygen control valve and the compressor in response to the measured oxygen content thereby to maintain the oxygen content within the first target range.
Closed-loop carbon dioxide content maintenance using air control valve
A controller arranged to define a second target range for said carbon dioxide content, to monitor the measured carbon dioxide content and to control the air control valve in response to the measured carbon dioxide content thereby to maintain the carbon dioxide content within the second target range.
Warm perfusion fluid with heater and thermometer
A perfusion system for the perfusion of an organ, the system comprising a perfusion fluid circuit for circulating a warm perfusion fluid through the organ, a heater to heat the perfusion fluid, and a thermometer to measure the temperature of the perfusion fluid.
Overall claim coverage is directed to maintaining oxygen content and carbon dioxide content of perfusion fluid within respective selectable target ranges during organ perfusion. The independent claims combine a permeable membrane oxygenator with an oxygen concentrator that uses nitrogen extraction from air, plus separate control of oxygen flow and air flow based on oxygen and carbon dioxide sensor measurements, with one independent claim further adding a heater and thermometer for warm perfusion fluid.
Stated Advantages
Documented Applications
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