Drug for the effective control of acute and or chronic pain and a method for its administration
Inventors
KOSORUKOV, Vyacheslav Stanislavovich • Rzhaninov, Evgeny Stanislavovic • KOROBOV, Nikolai Vasilievich
Assignees
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Publication Number
US-10357533-B2
Publication Date
2019-07-23
Expiration Date
Abstract
The proposed drug relates to medicine and veterinary applications, in particular, as a means for effective control of acute and/or chronic pain, and may be used in emergency medicine for the treatment of acute and/or chronic pain, including the late stages of cancer. The stated means is based on a compound for preventing and/or treating acute or chronic pain in a subject, including an analgesic peptide having an amino acid sequence H-Tyr-D-Arg-Phe-Gly-NH2 or an amino acid sequence H-Tyr-D-Arg-Phe-Sar-OH. Also, a method of use/administration of the compound for the prevention and/or treatment of acute and/or chronic pain is disclosed.
Core Innovation
The document describes compositions for injection and/or nasal administration intended to prevent or treat acute and/or chronic pain. Each composition contains one of two specified tetrapeptides as an active ingredient together with at least one pharmaceutical excipient. Dependent claims further identify excipient classes and substances, including stabilizers and release modifiers, as well as dosage forms, administration routes, and formulation characteristics.
The supplied partial content does not include the background section, so it does not explicitly identify the problem being solved. Reported animal studies describe dose-dependent analgesia, with some results comparable to or greater than morphine; chronic dosing studies report no observed tolerance or withdrawal. Formulation examples report extended storage stability, and limited clinical use for severe cancer or traumatic pain reports relief without observed respiratory depression or impaired consciousness.
Claims Coverage
The supplied relevant claims identify one inventive feature across one independent claim.
Tetrapeptide pain-treatment composition
The independent claim covers a composition for injection and/or nasal administration to prevent and/or treat acute and/or chronic pain. It comprises a therapeutically efficacious quantity of one of the two specified tetrapeptides as an active ingredient and at least one excipient.
The independent claim centers on a pain-treatment composition combining one of the specified tetrapeptides with at least one excipient for injection and/or nasal administration.
Stated Advantages
Animal studies report dose-dependent analgesia, with some test results comparable to or greater than morphine.
Chronic dosing studies report no observed tolerance or withdrawal.
Formulation examples report extended storage stability.
Limited clinical use reports pain relief without observed respiratory depression or impaired consciousness.
Documented Applications
The claimed compositions are intended for preventing and/or treating acute and/or chronic pain through injection and/or nasal administration.
The document describes limited clinical use for severe cancer or traumatic pain.
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