Diagnostics systems and methods
Inventors
Galen, Peter • GURKAN, UMUT ATAKAN • FRAIWAN, ARWA • HASAN, MUHAMMAD NOMAN • Grupp, Daniel E. • Hoyt, Joshua King • Thorne, James • Grimberg, Brian T.
Assignees
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Publication Number
US-10349589-B2
Publication Date
2019-07-16
Expiration Date
Abstract
A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease and/or infection of the patient.
Core Innovation
A point-of-care diagnostic system is provided in which a cartridge receives and stores a patient blood sample containing one or more hemoglobin types within a blood sample chamber. The cartridge includes an electrophoresis strip structured to receive at least a portion of the patient blood sample and to receive a selectively applied electric current. A reader receives the cartridge in a cartridge receptacle and initiates an electrophoresis diagnostic process in response to receiving the cartridge.
The reader includes an electrophoresis module configured to apply the selectively applied electric current to the electrophoresis strip of the cartridge so that electrophoresis is performed on the at least a portion of the patient blood sample. The reader further includes an electrophoresis band detection module structured to detect one or more bands of at least a portion of the patient blood sample on the electrophoresis strip caused by the selectively applied electric current. The band detection module generates band detection data based on the one or more bands.
A processor receives the band detection data and analyzes the band detection data to determine one or more band characteristics for each of the one or more bands, where each band corresponds to one of the one or more hemoglobin types. The processor identifies the one or more hemoglobin types of the patient blood sample based on the one or more band detection characteristics of each band. The processor then generates diagnostic results based at least in part on the one or more identified hemoglobin types and transmits the diagnostic results to an output.
Claims Coverage
The independent claim is directed to a point-of-care cartridge-and-reader system that performs electrophoresis on patient blood containing one or more hemoglobin types, detects electrophoresis bands, analyzes band characteristics to identify hemoglobin types, and generates and transmits diagnostic results. The main inventive features are captured in the independent claim.
Point-of-care cartridge for hemoglobin electrophoresis
A cartridge having a blood sample chamber structured to receive and store a patient blood sample containing one or more hemoglobin types and an electrophoresis strip structured to receive at least a portion of the patient blood sample and to receive a selectively applied electric current.
Reader to run electrophoresis and detect bands
A reader having a cartridge receptacle shaped to receive the cartridge and initiate an electrophoresis diagnostic process, an electrophoresis module structured to cause the selectively applied electric current to be applied to the electrophoresis strip, and an electrophoresis band detection module structured to detect one or more bands and generate band detection data based on the one or more bands.
Processor analysis to identify hemoglobin types and generate results
A processor programmed to receive the band detection data, analyze the band detection data to determine one or more band characteristics for each band, identify the one or more hemoglobin types corresponding to the band characteristics, generate diagnostic results based at least in part on the identified hemoglobin types, and transmit the diagnostic results to an output.
Across the independent claim, the system ties together cartridge-based electrophoresis of a patient blood sample containing hemoglobin types, reader-based band detection, and processor-based analysis of band characteristics to identify hemoglobin types and produce diagnostic results for output.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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