Medicament delivery devices for administration of a medicament within a prefilled syringe
Inventors
Edwards, Eric S. • Edwards, Evan T. • Licata, Mark J. • Meyers, Paul F.
Assignees
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Publication Number
US-10342924-B2
Publication Date
2019-07-09
Expiration Date
Abstract
An apparatus includes a housing, a medicament container and a movable member. The medicament container is configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member is configured to exert the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member is configured to exert a retraction force on the flange to move the medicament container from the second position towards the first position.
Core Innovation
A medicament delivery device includes a prefilled syringe assembly having a syringe body containing a medicament and a needle staked to the syringe body, with a proximal end portion including a flange. A syringe enclosure defines an internal volume in which the proximal end portion is disposed before and during injecting, while a distal end of the needle extends beyond a distal end surface of the syringe enclosure before and during injecting.
The method includes removing the medicament delivery device from a case, where the case obstructs a view of the medicament within the syringe body before removal, followed by viewing the medicament after removal. The distal end portion of the medicament delivery device is placed into contact with a target location, and an actuator is moved or actuated to cause a force to be exerted on a proximal end of the piston member. This force moves the piston member within the syringe body from a first position to a second position to convey a dose through the needle into the target location.
The syringe enclosure has first stop surface and second stop surface features that engage the flange and limit movement of the prefilled syringe assembly and distal movement of the piston member. In the detailed mechanics described, latch and release cooperation holds the medicament delivery mechanism in a storage configuration and then disengages to allow a spring-driven transfer member and piston engagement shoulders to move the medicament container and piston, including deformable engagement members that switch from needle-insertion to medicament-delivery modes and isolate the plunger during needle insertion to reduce leakage.
Claims Coverage
The independent claims cover injecting a medicament using a prefilled syringe assembly removed from a case and actuator-driven piston movement through a staked needle, with stop-surface features limiting component travel. The claims also recite case-obstructed viewing before removal and viewing after removal, and a syringe enclosure defining an internal volume with the needle extending beyond a distal end surface.
Case obstructing view and post-removal viewing of medicament
Removing a medicament delivery device from a case, wherein the case obstructs a view of the medicament within the syringe body before removing, and viewing the medicament after the removing.
Actuator-driven force on piston to convey dose through needle into target location
Moving the actuator to cause a force to be exerted on a proximal end of the piston member to move the distal end of the piston member within the syringe body from a first position to a second position to convey a dose of the medicament from the syringe body through the needle into the target location.
Stop surfaces limiting movement of prefilled syringe assembly and piston
A proximal end of the syringe enclosure including a first stop surface and a second stop surface, the second stop surface engaging the flange to limit movement of the prefilled syringe assembly within the syringe enclosure, and the first stop surface limiting distal movement of the piston member when the piston member is at the second position within the syringe body.
Syringe enclosure internal volume with needle extending beyond enclosure distal end surface
A syringe enclosure defining an internal volume within which the proximal end portion of the syringe body is disposed before and during the injecting the medicament, and a distal end of the needle extending beyond a distal end surface of the syringe enclosure before and during the injecting the medicament.
Actuator configured to be limited by case before removing
The actuator configured to move to initiate the injecting the medicament, wherein the case limiting movement of the actuator before the removing.
The independent claims collectively cover injecting a medicament by removing a prefilled syringe assembly from a case, with viewing obstruction before removal and viewing after removal, positioning against a target location, and actuating an actuator to apply force to a piston that moves from a first to a second position to convey a dose through a staked needle, while stop surfaces limit movement of the prefilled syringe assembly and distal movement of the piston.
Stated Advantages
Documented Applications
Injecting a medicament using a prefilled syringe assembly in contact with a target location after removing the device from a case.
Viewing the medicament after removing the medicament delivery device from a case.
Targeting a location for injection, including a target location specified as a thigh [procedural detail omitted for safety].
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