Electrochemical gasotransmitter generating compositions and methods of using same and dressings and treatment systems incorporating same
Inventors
Assignees
Publication Number
US-10342706-B2
Publication Date
2019-07-09
Expiration Date
2038-01-18
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Abstract
Disclosed are compositions that comprise an organic electrochemical mediator and a gasotransmitter salt which converts into a gasotransmitter via electron transfer. Also disclosed are bandages and wound dressings comprising the subject gasotransmitters, and methods of making a gasotransmitters, comprising exposing the compositions to a voltage sufficient to reduce the water soluble organic mediator. Further disclosed are methods of treating a variety of trauma and disease states by applying a therapeutically effective amount of at least one gasotransmitter thereto, and methods of generating an effective dose of the gasotransmitter generated from electrolytic reaction involving the gasotransmitter-generating compositions.
Core Innovation
The invention relates to compositions comprising an organic electrochemical mediator and a gasotransmitter salt which, upon reduction, generate gasotransmitters such as nitric oxide or hydrogen sulfide. These compositions can be applied in therapeutic dressings and bandages where the gasotransmitter generation is controlled by applying a voltage sufficient to reduce the water soluble organic mediator. The invention allows the production of gasotransmitters via an electrochemical reaction involving electron transfer mediated by the organic electrochemical mediator.
The problem being addressed is the difficulty in delivering gasotransmitters in a controlled, targeted, and temporally variable manner due to their gaseous state at ambient temperature, short half-lives in physiological environments, and the complexity of their time-dependent concentration profiles necessary for biological processes such as wound healing. Prior methods either require sealing treated areas, rely on limited control release profiles, or face issues such as electrode passivation.
The disclosed approach overcomes these challenges by using an organic mediator to electrochemically reduce gasotransmitter salts in situ, enabling precise control over gasotransmitter flux spatially and temporally. The invention includes dressings and bandages integrated with a gasotransmitter generating composition, electrodes, a power source, and optional voltage controllers or microprocessors for active control of gas generation, thus enabling therapeutic application tailored to various medical needs.
Claims Coverage
The patent contains one independent claim directed to a therapeutic dressing comprising key components, and several dependent claims detailing particular features of these components and configurations. The independent claim establishes the core structure of the therapeutic dressing incorporating the inventive gasotransmitter generating system.
Therapeutic dressing with electrochemical gasotransmitter generation
A therapeutic dressing comprising (a) a composition including (i) an organic electrochemical mediator configured to reduce a gasotransmitter salt; and (ii) the gasotransmitter salt which converts into a gasotransmitter upon reduction; (b) a carrier adapted to contain the composition; and (c) a source of current in electrical contact with the composition capable of producing the gasotransmitter.
Gasotransmitter salt selection
The gasotransmitter salt is selected from nitrate, nitrite, sulfate, thiosulfate, and sulfite salts, including specific cationic compositions such as sodium, potassium, calcium, and magnesium salts.
Electrochemical mediator characteristics
The electrochemical mediator has a reduction potential in the range of about -0.1 V to about -2.0 V, preferably from about -0.5 V to about -1.7 V or about -0.75 V to about -1.5 V, and is selected from benzophenones, quinones, fluorescein, xanthone, thioxanthone, ketones or derivatives thereof, with a redox moiety and a hydrophilic moiety chosen from various polar functional groups and polymers.
Bandage construction with electrical control
A bandage constructed to maintain the therapeutic dressing at a target site, optionally including a voltage controller controlling the current from the source of current.
The claims broadly cover a therapeutic dressing system comprising an electrochemical mediator and gasotransmitter salt capable of generating gasotransmitters upon electrochemical reduction, integrated into a carrier with electrical current source. The claims specify mediator reduction potentials, chemical salt compositions, mediator functional groups, and bandage systems with current control, outlining a controlled gasotransmitter delivery method within therapeutic articles.
Stated Advantages
Enables controlled, targeted, and temporal delivery of gasotransmitters at therapeutic sites.
Overcomes challenges of delivering unstable gaseous signaling molecules by in situ electrochemical generation.
Avoids issues related to electrode passivation and compatibility with open wounds through use of an organic mediator.
Allows precise regulation of gasotransmitter flux by adjusting formulation and applied current.
Facilitates therapeutic treatment of wounds and disease states by controlled gasotransmitter exposure.
Documented Applications
Treatment of wounds and trauma by applying therapeutically effective gasotransmitter amounts.
Use in dressings and bandages for controlled generation and application of nitric oxide and hydrogen sulfide.
Therapeutic management of acne vulgaris by applying gasotransmitter generating compositions.
Treatment of skin ulcers with therapeutic gasotransmitter generating bandages.
Treatment of viral infections by bringing virus sites into therapeutic proximity with gasotransmitter generating compositions.
Application in oral care compositions for cleaning, plaque control, anti-inflammatory, anti-microbial, and oral health benefits.
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