Bioactive porous bone graft implants
Inventors
Bagga, Charanpreet S. • JUNG, Steve B. • Bae, Hyun W.
Assignees
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Publication Number
US-10335516-B2
Publication Date
2019-07-02
Expiration Date
Abstract
Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.
Core Innovation
The disclosed invention provides a porous, composite bone graft implant made from bioactive glass. The implant includes at least one cluster with a matrix of randomly oriented bioactive glass fibers and bioactive glass particulates in the form of microspheres distributed throughout the bioactive glass fibers, and at least some of the fibers and particulates are sintered together.
The cluster is at least partially encased by a bioactive shell comprising bioactive glass, which is at least partially sintered to the matrix. The implant is engineered so that the fibers, particulates, and the bioactive shell each have a different resorption rate, and this structural differentiation is used to support remodeling over a healing time by promoting cell attachment, resorption timing, and the formation of a calcium phosphate layer.
The implant further incorporates engineered porosity with a pore size distribution extending from nano-to-macropores, including pores having diameters of about 100 nanometers to about 1 millimeter. Multiple implant formats are disclosed for customization and handling, including putty, foam, fibrous matrix, fibrous clusters, and granular matrix.
Claims Coverage
The disclosed portion includes one independent claim. The independent claim requires a porous composite bone graft implant with a sintered fiber/microsphere cluster encased by a bioactive shell, where fibers, particulates, and shell each have different resorption rates.
Sintered randomly oriented fiber-microsphere cluster with encasing bioactive shell
A porous composite bone graft implant including at least one cluster with a matrix of randomly oriented bioactive glass fibers and bioactive glass particulates comprising microspheres distributed throughout the bioactive glass fibers, where at least some fibers and particulates are sintered together and a bioactive shell comprising bioactive glass at least partially encases and is at least partially sintered to the matrix.
Differential resorption rates among fibers, particulates and shell
The fibers, particulates, and the bioactive shell each have a different resorption rate.
Coverage is centered on a porous composite bone graft implant formed from a sintered cluster of randomly oriented bioactive glass fibers with microsphere particulates, encased and partially sintered by a bioactive glass shell, with different resorption rates for the fiber, particulate, and shell components.
Stated Advantages
Supports remodeling over healing time by sustaining processes associated with bioactive glass implants, including cell attachment, resorption timing, and CaP layer formation.
Enables improved handling and molding/customization through multiple implant formats including putty, foam, fibrous matrix, fibrous clusters, and granular matrix.
Allows customization of biological and functional performance through optional incorporation of biological agents, growth factors, trace elements/metals, antimicrobials, and drug delivery capabilities.
Documented Applications
Bone graft implantation using porous, composite bioactive glass implants configured for remodeling during healing time.
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