Bi-phasic paired pulse transcranial magnetic stimulation
Inventors
Neuvonen, Tuomas • Hannula, Henri • Jarnefelt, Gustaf • Laine, Jarmo
Assignees
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Publication Number
US-10300294-B2
Publication Date
2019-05-28
Expiration Date
Abstract
It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.
Core Innovation
The invention provides a method of recording a response to Transcranial Magnetic Stimulation (TMS) by inducing a bi-phasic double pulse pair from a single stimulation coil of a TMS coil device to stimulate a subject. The second bi-phasic pulse has a lower amplitude compared to the first bi-phasic pulse in the bi-phasic double pulse pair, and the subject's response to the bi-phasic double pulse pair is measured.
A key element of the method is that no magnetic field is generated by the TMS coil device between the conclusion of the second bi-phasic pulse and prior to the measurement of at least a first portion of the subject response. The approach is described in the context of response recording, where an initial portion of the subject response is measured after a no-magnetic-stimulation window following the second pulse.
The described system and rationale relate to reducing the pulse count/intensity and improving recording accuracy. The patent content states that reduced pulse count/intensity can reduce measurement-device interference and noise, supporting more accurate measurement of response features such as motor threshold, motor mapping outputs, and response timing and amplitude.
Claims Coverage
Independent claim clm-00001 defines the overall response-recording method and includes two main inventive features: a bi-phasic double pulse pair delivered from a single stimulation coil with a lower-amplitude second pulse, and a no magnetic field window after the second pulse before measuring at least a first portion of the response.
Lower-amplitude second bi-phasic pulse in a bi-phasic double pulse pair from a single stimulation coil
Inducing a bi-phasic double pulse pair from a single stimulation coil of a TMS coil device wherein the second bi-phasic pulse has a lower amplitude compared to the first bi-phasic pulse in the bi-phasic double pulse pair.
No magnetic field between second pulse and measurement of at least a first portion of the response
Generating no magnetic field by the TMS coil device between the conclusion of the second bi-phasic pulse and prior to the measurement of at least a first portion of the subject response.
The claim coverage centers on delivering a bi-phasic double pulse pair from a single coil with a lower-amplitude second pulse, combined with a no-magnetic-stimulation window after the second pulse to enable measuring at least a first portion of the subject response.
Stated Advantages
Reduced pulse count/intensity to improve accuracy.
Reduced measurement-device interference and noise.
Improved measurement of response features including motor mapping results and motor threshold comparisons using paired-pulse paradigms.
Documented Applications
Motor mapping using an APB hotspot and a tibialis anterior (TA) hotspot, with response measurement for motor threshold (MT) outcomes.
Measurement of subject responses using motor mapping paradigms, including paired-pulse paradigms such as 3/7/15 ms ISI, with recorded outcomes including MEP amplitude and latency.
Recording subject responses using measurement modalities including EEG, microphone, and video recorder (and combinations).
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