Substrate having an electron donating surface with metal particles comprising palladium on said surface
Inventors
Ohrlander, Mattias • Södervall, Billy
Assignees
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Publication Number
US-10300174-B2
Publication Date
2019-05-28
Expiration Date
Abstract
There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopedic implants, orthopedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.
Core Innovation
The invention relates to an object or substrate having an electron donating surface bearing uniformly distributed palladium-containing metal particles. The metal particles comprise palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum, and the metal-particle loading is from about 0.001 to about 8 bcg/cm2.
The disclosed approach provides controllable tuning of surface properties based on the composition and surface loading of the metal particles on the electron donating surface. The tuned surface properties include hydrophobicity and protein adsorption, and additional tuning outcomes include bacterial adhesion and bacterial growth, complement activation and inflammatory response, thrombogenicity, friction, and hardness.
The disclosed materials are applied to coated biomedical devices and device surfaces, where contacting the patient with the treated object is used for treatment and for providing hospital care with reduced risk. The document describes antimicrobial effects across multiple species and reduced complement activation and thrombogenic markers under adjusted metal compositions.
Claims Coverage
Two independent claims are identified: clm-00001 and clm-00014. Each claim requires contacting a patient with an object having an electron donating surface bearing palladium-containing metal particles with at least one specified noble metal, and each limits the metal-particle amount to from about 0.001 to about 8 bcg/cm2.
Treating a patient by contacting with an object having an electron donating surface
A method of treating a patient comprising contacting the patient with an object having an electron donating surface, wherein metal particles on the electron donating surface comprise palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum, and wherein the amount of the metal particles is from about 0.001 to about 8 bcg/cm2.
Providing hospital care with reduced risk of nosocomial infection by contacting with an object
A method of providing hospital care for a patient with reduced risk that the patient acquires a nosocomial infection, comprising contacting an object with the patient, wherein the object has an electron donating surface, the metal particles comprise palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum, and the amount of the metal particles is from about 0.001 to about 8 bcg/cm2.
Across both independent claims, the core coverage is provided by patient contacting using an object with an electron donating surface carrying palladium-containing metal particles that include at least one specified noble metal, with the amount limited to about 0.001 to about 8 bcg/cm2.
Stated Advantages
Reduced risk that the patient acquires a nosocomial infection.
Reduced complement activation and inflammatory response.
Reduced thrombogenicity and platelet adhesion-related markers.
Antimicrobial effects via tuning of bacterial adhesion and bacterial growth across multiple species.
Documented Applications
Treatment of a patient by bringing an object into contact with the patient, where the object has an electron donating surface bearing palladium-containing metal particles.
Providing hospital care for a patient with reduced risk of acquiring a nosocomial infection by contacting the patient with the treated object.
Coated biomedical device use cases described for catheters, stents, implants, dialysis equipment, and ECG electrodes, among other enumerated medical device and implant types.
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