Topical composition comprising extracts of boldo and of meadowsweet, intended for an animal, and uses thereof
Inventors
Assignees
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Publication Number
US-10300012-B2
Publication Date
2019-05-28
Expiration Date
Abstract
The invention relates to a topical veterinary composition for animals. It is characterized in that it comprises, in a physiologically acceptable medium, extracts of boldo Peumus boldus and extracts of meadowsweet Spiraea ulmaria. The invention applies in particular to preventing or treating or to assisting with the control of microbial infections.
Core Innovation
The invention relates to a topical composition for animals comprising, in a physiologically acceptable medium, an extract of boldo Peumus boldus and an extract of meadowsweet Spiraea ulmaria. The extract of boldo and the extract of meadowsweet are present within specified weight ranges of the total weight of the composition. The composition is formulated as a skin disinfectant for an animal or as an ear cleaner for an animal.
The composition is positioned for preventing, treating, or assisting in controlling microbial infections in an animal. The disclosed approach is directed to stimulating innate skin antimicrobial peptides, including canine beta-defensin cBD103 and/or cathelicidin cCath, in the context of skin and ear use. The formulation is described as being designed not to trigger pro-inflammatory cytokines, including without an IL-8 increase and without a TNF-α increase.
The document further reports that, in vitro, boldo and meadowsweet effects can differ between normal and atopic cells, and that the combination can synergistically increase antimicrobial peptide output, including cCath. In vitro data are also described indicating that tested products do not increase IL-8 or TNF-α.
Claims Coverage
Only one independent claim is provided in the partial content. It defines the overall scope with three main inventive components: a two-plant extract system (boldo and meadowsweet) in a physiologically acceptable medium with specified concentration ranges, and formulation for skin disinfection or ear cleaning in animals.
Topical composition with boldo and meadowsweet extracts in physiologically acceptable medium
A topical composition for animals, comprising, in a physiologically acceptable medium, an extract of boldo Peumus boldus and an extract of meadowsweet Spiraea ulmaria.
Specified extract weight ranges of boldo and meadowsweet
Wherein the extract of boldo represent from 0.00005% to 1% by weight of a total weight of the composition, and wherein the extract of meadowsweet represent from 0.00001% to 0.2% by weight of the total weight of the composition.
Formulated as skin disinfectant or ear cleaner for an animal
Wherein the composition is formulated as a skin disinfectant for an animal or as an ear cleaner for an animal.
The claim coverage provided by the partial content centers on a topical veterinary composition containing boldo and meadowsweet extracts in a physiologically acceptable medium at defined weight ranges, configured as either a skin disinfectant or an ear cleaner for animals.
Stated Advantages
Prevents, treats, or assists in controlling microbial infections.
Stimulates innate skin antimicrobial peptides (canine beta-defensin cBD103 and/or cathelicidin cCath).
Does not trigger pro-inflammatory cytokines, including no IL-8 increase and no TNF-α increase.
In vitro tested products do not increase IL-8 or TNF-α.
Documented Applications
Formulated as a skin disinfectant for an animal.
Formulated as an ear cleaner for an animal.
Example shampoo use case for Malassezia pachydermatis.
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