Implantable scaffolds and methods for treatment of sinusitis
Inventors
You, Changcheng • Pham, Quynh • Concagh, Danny • Zugates, Gregory
Assignees
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Publication Number
US-10278812-B2
Publication Date
2019-05-07
Expiration Date
Abstract
This disclosure describes, inter alia, materials, devices, kits and methods for the treatment of chronic sinusitis. Disclosed are medical scaffolds configured for placement within a sinus of a patient, methods of making the implants and methods of treatment. The scaffolds comprise a woven or non-woven structure having a substantially tubular configuration, a conformal coating over the tubular scaffold and optionally, a drug coating.
Core Innovation
The disclosed invention is a self-expanding, generally tubular sinus scaffold comprising braided biodegradable polymer strands and a conformal coating of crosslinked biodegradable elastomer. The scaffold is configured to fit the shape of a sinus cavity and provide patency and tissue conformity. Optional drug-containing layers, including mometasone furoate with polymer carriers and topcoats, enable tunable local release.
The background section is not included, so the problem being solved is not explicitly described in patent. The content describes scaffold compression, recovery, and radial-force measurements, alongside sinus placement, cadaver deployment, and catheter-based delivery. Controlled in-vitro drug-release profiles, rabbit sinus drug-release data, sinus drug concentration, and in-vivo drug retention are also reported.
Claims Coverage
The provided relevant claims identify one independent claim with one inventive feature directed to a scaffold configured for implantation into a human sinus.
Braided tubular scaffold with a conformal elastomer coating
A tubular scaffold comprising a plurality of braided polymeric strands that comprise a first biodegradable polymer material, with a conformal coating over the tubular scaffold comprising a crosslinked biodegradable elastomer material. The elastomer material is formed by reacting a branched poly(lactide-co-caprolactone) polyol with a diisocyanate crosslinking agent, and the scaffold is adapted to conform to the shape of the sinus cavity.
The independent claim covers the combination of a braided biodegradable tubular scaffold, a conformal crosslinked biodegradable elastomer coating, and adaptation to the shape of a human sinus cavity.
Stated Advantages
The scaffold is configured to provide patency and tissue conformity.
Optional drug-containing layers enable tunable local release.
Documented Applications
Scaffold configured for implantation and deployment in a human sinus.
Catheter-based delivery of the scaffold.
Local therapeutic-agent release from drug-containing scaffold layers, including mometasone furoate.
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